PMID: 3755180Jan 1, 1986Paper

Dose-dependent nonlinear response of the main phase-transition temperature of phospholipid membranes to alcohols

The Journal of Membrane Biology
H KamayaS H Lin

Abstract

The effect of 1-alkanols upon the main phase-transition temperature of phospholipid vesicle membranes between gel and liquid-crystalline phases was not a simple monotonic function of alkanol concentration. For instance, 1-decanol decreased the transition temperature at low concentrations, but increased it at high concentrations, displaying a minimal temperature. This concentration-induced biphasic effect cannot be explained by the van't Hoff model on the effect of impurities upon the freezing point. To explain this nonlinear response, a theory is presented which treats the effect of 1-alkanols (or any additives) on the transition temperature of phospholipid membranes in a three-component mixture. By fitting the experimental data to the theory, the enthalpy of the phase transition delta H* and the interaction energy, epsilon*AB between the additive and phospholipid molecules may be estimated. The theory predicts that when epsilon*AB greater than 2 (where epsilon*AB = epsilon AB/RT0, T0 being the transition temperature of phospholipid), both minimum and maximum transition temperatures should exist. When epsilon*AB = 2, only one inflection point exists. When epsilon*AB less than 2, neither maximum nor minimum exists. The alkanol c...Continue Reading

References

Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Mabrey, J M Sturtevant
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Citations

Mar 22, 1988·Biochimica Et Biophysica Acta·P W WestermanD W Dubro
Mar 1, 1991·Chemistry and Physics of Lipids·K Lohner
Apr 1, 1994·Progress in Neurobiology·J R Elliott, A A Elliott
Jun 6, 2002·Chemistry and Physics of Lipids·Rumiana Koynova, Martin Caffrey
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S N Treistman, A Wilson
May 24, 2014·Biophysical Journal·Kaare GraesbøllThomas Heimburg
Oct 16, 1987·Biochimica Et Biophysica Acta·D E Epps, A D Cardin
Jul 1, 1987·Reviews in Clinical & Basic Pharmacology·A C Swann
Sep 25, 1998·The Journal of Laryngology and Otology·D SalvanB Luboinski

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