PMID: 590308Nov 14, 1977

Dose dependent pharmacokinetics of prednisolone

European Journal of Clinical Pharmacology
M PickupW W Downie


The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.


Apr 4, 1975·European Journal of Clinical Pharmacology·P J Fell, M T Stevens
Jan 1, 1976·Drug Metabolism Reviews·W J Jusko, M Gretch
Sep 11, 1976·British Medical Journal·T D Swinscow
Oct 1, 1975·Journal of Pharmaceutical Sciences·T J SullivanJ G Wagner
Jan 1, 1975·Journal of Pharmaceutical Sciences·A R DiSanto, K A Desante
Oct 1, 1975·The Journal of Clinical Endocrinology and Metabolism·A W MeikleF H Tyler
Aug 1, 1975·British Journal of Clinical Pharmacology·C G WilsonJ W Paterson
Dec 1, 1970·Biochemical Medicine·D H SandbergW W Cleveland
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·E Jähnchen, G Levy
Jun 1, 1973·Steroids·W A Colburn, R H Buller
Mar 1, 1974·The Journal of Clinical Endocrinology and Metabolism·M KozowerM M Kaplan
Jul 1, 1971·Journal of Pharmaceutical Sciences·P F D'ArcyA W Peacock
Apr 1, 1972·Journal of Pharmaceutical Sciences·A R DiSanto, J G Wagner
Jun 1, 1970·Journal of Pharmaceutical Sciences·W J Jusko, G Levy
Jan 1, 1968·Journal of Pharmaceutical Sciences·S RiegelmanM Rowland
Jul 1, 1965·Journal of Pharmaceutical Sciences·G Levy
May 1, 1959·The Journal of Endocrinology·A VERMEULEN


Jan 1, 1986·European Journal of Clinical Pharmacology·S J SzeflerW J Jusko
Jan 1, 1984·European Journal of Clinical Pharmacology·B M FreyF J Frey
Jan 1, 1981·European Journal of Clinical Pharmacology·W A McAllisterJ V Collins
Jan 1, 1983·European Journal of Clinical Pharmacology·H BergremH E Rugstad
Jan 1, 1985·European Journal of Clinical Pharmacology·S EdsbäckerA Ryrfeldt
Jan 1, 1986·European Journal of Clinical Pharmacology·D LoewE H Graul
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·M PickupC O Record
Feb 24, 2007·Journal of Pharmacokinetics and Pharmacodynamics·J XuH Derendorf
Feb 1, 1994·Steroids·F J FreyB M Frey
Jul 19, 1980·Lancet·H A BirdD Galloway
Feb 1, 1993·Pharmacology & Toxicology·G S LaustenK Olgaard
Nov 15, 2001·Clinical Pharmacokinetics·M Schwab, U Klotz
Mar 28, 2007·Journal of Pharmaceutical Sciences·M VogtD M Barends
Oct 14, 2006·Journal of Pharmaceutical Sciences·M VogtD M Barends
Apr 1, 1982·Kidney International·J G GambertoglioW J Amend
Nov 1, 1980·British Journal of Clinical Pharmacology·S Al-Habet, H J Rogers
Jun 1, 1985·The Journal of Pediatrics·L OstA Rane
Jun 1, 1979·The Journal of Pediatrics·J Q RoseO C Green
Feb 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·J G GambertoglioL Z Benet
Dec 11, 1992·Journal of Pharmacokinetics and Biopharmaceutics·J A WaldW J Jusko
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·J Q RoseW J Jusko
Oct 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·M L Huang, W J Jusko
May 27, 2015·European Journal of Clinical Pharmacology·E G QuetglasSilvio Danese
Dec 1, 1993·Biopharmaceutics & Drug Disposition·H Cheng, W J Jusko
Oct 1, 1985·Biopharmaceutics & Drug Disposition·H DerendorfD Neveling
Jan 1, 1986·Biopharmaceutics & Drug Disposition·J J Ferry, J G Wagner
Jul 1, 1981·Biopharmaceutics & Drug Disposition·J C LooR Brien
Sep 1, 1989·Biopharmaceutics & Drug Disposition·H MöllmannH Derendorf
Aug 20, 2019·Therapeutic Drug Monitoring·Emily BrooksChristine E Staatz
Oct 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·V G HaleL Z Benet
Nov 1, 1978·The Journal of Pharmacy and Pharmacology·J C LooR Brien
Aug 8, 2018·Dose-response : a Publication of International Hormesis Society·Tafsir BasharAbul Hasnat
Jun 1, 1983·The Journal of Pharmacy and Pharmacology·J R Lowe, J S Dixon
Jan 1, 1984·Acta Medica Scandinavica·S BjörckG Stelin

Related Concepts

Dose-Response Relationship, Drug
Intravenous Injections

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Journal of Pharmacokinetics and Biopharmaceutics
J Q RoseW J Jusko
The Journal of Clinical Endocrinology and Metabolism
U F LeglerL Z Benet
© 2021 Meta ULC. All rights reserved