PMID: 590308Nov 14, 1977

Dose dependent pharmacokinetics of prednisolone

European Journal of Clinical Pharmacology
M PickupW W Downie

Abstract

The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.

References

Apr 4, 1975·European Journal of Clinical Pharmacology·P J Fell, M T Stevens
Jan 1, 1976·Drug Metabolism Reviews·W J Jusko, M Gretch
Sep 11, 1976·British Medical Journal·T D Swinscow
Oct 1, 1975·Journal of Pharmaceutical Sciences·T J SullivanJ G Wagner
Jan 1, 1975·Journal of Pharmaceutical Sciences·A R DiSanto, K A Desante
Oct 1, 1975·The Journal of Clinical Endocrinology and Metabolism·A W MeikleF H Tyler
Aug 1, 1975·British Journal of Clinical Pharmacology·C G WilsonJ W Paterson
Dec 1, 1970·Biochemical Medicine·D H SandbergW W Cleveland
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·E Jähnchen, G Levy
Jun 1, 1973·Steroids·W A Colburn, R H Buller
Mar 1, 1974·The Journal of Clinical Endocrinology and Metabolism·M KozowerM M Kaplan
Jul 1, 1971·Journal of Pharmaceutical Sciences·P F D'ArcyA W Peacock
Apr 1, 1972·Journal of Pharmaceutical Sciences·A R DiSanto, J G Wagner
Jun 1, 1970·Journal of Pharmaceutical Sciences·W J Jusko, G Levy
Jan 1, 1968·Journal of Pharmaceutical Sciences·S RiegelmanM Rowland
Jul 1, 1965·Journal of Pharmaceutical Sciences·G Levy
May 1, 1959·The Journal of Endocrinology·A VERMEULEN

Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·S J SzeflerW J Jusko
Jan 1, 1984·European Journal of Clinical Pharmacology·B M FreyF J Frey
Jan 1, 1981·European Journal of Clinical Pharmacology·W A McAllisterJ V Collins
Jan 1, 1983·European Journal of Clinical Pharmacology·H BergremH E Rugstad
Jan 1, 1985·European Journal of Clinical Pharmacology·S EdsbäckerA Ryrfeldt
Jan 1, 1986·European Journal of Clinical Pharmacology·D LoewE H Graul
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·M PickupC O Record
Feb 24, 2007·Journal of Pharmacokinetics and Pharmacodynamics·J XuH Derendorf
Feb 1, 1994·Steroids·F J FreyB M Frey
Jul 19, 1980·Lancet·H A BirdD Galloway
Feb 1, 1993·Pharmacology & Toxicology·G S LaustenK Olgaard
Nov 15, 2001·Clinical Pharmacokinetics·M Schwab, U Klotz
Mar 28, 2007·Journal of Pharmaceutical Sciences·M VogtD M Barends
Oct 14, 2006·Journal of Pharmaceutical Sciences·M VogtD M Barends
Apr 1, 1982·Kidney International·J G GambertoglioW J Amend
Nov 1, 1980·British Journal of Clinical Pharmacology·S Al-Habet, H J Rogers
Jun 1, 1985·The Journal of Pediatrics·L OstA Rane
Jun 1, 1979·The Journal of Pediatrics·J Q RoseO C Green
Feb 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·J G GambertoglioL Z Benet
Dec 11, 1992·Journal of Pharmacokinetics and Biopharmaceutics·J A WaldW J Jusko
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·J Q RoseW J Jusko
Oct 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·M L Huang, W J Jusko
May 27, 2015·European Journal of Clinical Pharmacology·E G QuetglasSilvio Danese
Dec 1, 1993·Biopharmaceutics & Drug Disposition·H Cheng, W J Jusko
Oct 1, 1985·Biopharmaceutics & Drug Disposition·H DerendorfD Neveling
Jan 1, 1986·Biopharmaceutics & Drug Disposition·J J Ferry, J G Wagner
Jul 1, 1981·Biopharmaceutics & Drug Disposition·J C LooR Brien
Sep 1, 1989·Biopharmaceutics & Drug Disposition·H MöllmannH Derendorf
Aug 20, 2019·Therapeutic Drug Monitoring·Emily BrooksChristine E Staatz
Oct 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·V G HaleL Z Benet
Nov 1, 1978·The Journal of Pharmacy and Pharmacology·J C LooR Brien
Aug 8, 2018·Dose-response : a Publication of International Hormesis Society·Tafsir BasharAbul Hasnat
Jun 1, 1983·The Journal of Pharmacy and Pharmacology·J R Lowe, J S Dixon
Jan 1, 1984·Acta Medica Scandinavica·S BjörckG Stelin

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