Dose-dependent prevention of sugar cataracts in galactose-fed dogs by the aldose reductase inhibitor M79175

Experimental Eye Research
S SatoP F Kador

Abstract

Sugar cataracts rapidly develop in dogs fed a diet containing 30% galactose. While studies on the formation and progression of these sugar cataracts suggest that they are osmotic in nature and are linked to aldose reductase, sugar cataract formation in the dog to date has not been completely prevented by the administration of aldose reductase inhibitors sorbinil and M79175. To demonstrate that the formation and progression of sugar cataracts in galactose-fed dogs can be dose-dependently inhibited by the administration of aldose reductase inhibitors, 9-month old male beagles were placed on diet containing 30% galactose with/without 10 or 16 mg kg-1 day-1 of M79175 for up to 39 months. Cataract progression in all dogs was followed by periodic slit lamp examination and documented by retroillumination photography. Although large variations in cataract formation and progression were observed, all dogs fed a 30% galactose diet for 39 months developed cataracts. Lens changes were significantly less in galactose-fed dogs treated with either 10 or 16 mg kg-1 M79175 and no cataract formation was observed in 3 of 6 galactose-fed dogs treated with 16 mg kg-1 M79175. These observations confirm that aldose reductase plays a key role in initi...Continue Reading

References

Jul 1, 1981·Indian Journal of Physiology and Pharmacology·N S Parmar, M N Ghosh
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A Y LeeS S Chung
Sep 1, 1994·Preventive Medicine·P F KadorM Wyman
Jan 1, 1993·Journal of Ocular Pharmacology·Y TakahashiP F Kador
Mar 1, 1997·Experimental Eye Research·P A LacknerP F Kador

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Citations

Sep 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·P F KadorK Sugiyama
Jan 5, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·M J LizakP F Kador
Aug 24, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorKaren Blessing
Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorUday B Kompella
Jun 2, 2010·International Journal of Molecular Medicine·Irina G ObrosovaCarl-David Agardh
Nov 22, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peng ZhangPeter F Kador
Apr 20, 2004·Veterinary Ophthalmology·Dolores J TakemotoLynn M Wagner
May 18, 2010·Diabetes/metabolism Research and Reviews·Irina G ObrosovaPeter F Kador
May 4, 2004·Journal of Diabetes and Its Complications·Z KyselovaV Bauer
Mar 12, 2016·Expert Opinion on Therapeutic Patents·Xin HaoChangjin Zhu
Jun 27, 2006·Experimental Eye Research·Carol B TorisPeter F Kador
Nov 5, 1999·Experimental Eye Research·S BanditelliU Mura
Apr 23, 2016·Progress in Retinal and Eye Research·Peter F KadorPeter J Oates
Feb 5, 2011·Pediatric Emergency Care·Neil G Uspal, Emily S Schapiro
Jun 18, 1999·Current Eye Research·E F SecchiP F Kador
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Bauyrzhan UmbayevDenis Bulanin

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