Dose dependent protective effects of vardenafil on ischemia-reperfusion injury with biochemical and histopathologic evaluation in rat ovary

Journal of Pediatric Surgery
Engin YurtcuNedim Cicek

Abstract

The purpose of the study is to evaluate the effect of vardenafil on the histopathology and biochemical parameters in reducing damage in experimental ovarian ischemia and ischemia/reperfusion injury in a rat model and to compare the effect of two different doses of vardenafil. Forty-two rats with experimental ovarian torsion. Group-I: sham; Group-II: ovarian ischemia; Group-III: 2 hours of ischemia followed by a 2-hour reperfusion. Group-IV: two hours before the sham operation, rats received 1mg/kg vardenafil; Group V and VI: A 2-hour period of ovarian ischemia was applied, in which rats were treated with intraperitoneal vardenafil 1 and 2mg/kg dose, after 1.5 hours of ovarian ischemia. After 2 hours of reperfusion, the ovaries on the right side were removed for examination. The ovarian ischemia/reperfusion injury was evaluated by calculating total antioxidant status, total oxidant status and oxidative stress index; and histopathologic examination of all ovarian rat tissue. The histologic findings in vardenafil treatment groups were statistically significant decreased edema and follicle degeneration, with vascular congestion, hemorrhage and follicle degeneration being dose-dependent. There were no statistically significant chang...Continue Reading

References

Jun 15, 1985·American Journal of Obstetrics and Gynecology·L T Hibbard
Jun 17, 1994·Annals of the New York Academy of Sciences·I Kurose, D N Granger
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Chuanyu Li, Robert M Jackson
Nov 5, 2003·American Journal of Respiratory and Critical Care Medicine·Toby J TowardKenneth J Broadley
Nov 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Onder CelikSaim Yologlu
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Aug 4, 2006·Clinical Obstetrics and Gynecology·Gabriel Oelsner, David Shashar
Jan 21, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Geetika Srivastava, Jawahar L Mehta
May 29, 2009·American Journal of Physiology. Renal Physiology·Dae Eun ChoiKang Wook Lee
Jul 28, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mustafa OzatSevda Muftuoglu
Mar 27, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mustafa KaraOzgul Tap

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Citations

Nov 30, 2018·The Journal of Obstetrics and Gynaecology Research·Ilkin YeralOzcan Erel
Nov 24, 2020·Fundamental & Clinical Pharmacology·Moein AlaAhmad Reza Dehpour
Jan 6, 2021·Archives of Gynecology and Obstetrics·Tuba ÇandarSarp Özcan

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