PMID: 2123200Nov 1, 1990Paper

Dose-dependent reduction of bone inductive properties by ethylene oxide

The Journal of Bone and Joint Surgery. British Volume
P AspenbergK G Thorngren

Abstract

Sterilisation of demineralised bone matrix with ethylene oxide has been claimed to destroy the ability of bone matrix to induce new bone formation on intramuscular implantation. Other workers have routinely used ethylene oxide sterilised bone matrix for assays in rodents without detrimental effects. We studied the effects of various lengths of exposure to ethylene oxide gas, and found that bone induction properties are destroyed in a dose-dependent manner. After a short exposure, bone induction properties were moderately diminished. However, this short ethylene oxide treatment did not kill Bacillus subtilis spores. A sterilisation procedure that killed these spores rendered the implants incapable of bone-induction.

Citations

Oct 1, 1991·Acta Orthopaedica Scandinavica·E M PinholtE Sudmann
May 4, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·T PekkarinenP Jalovaara
Mar 10, 2010·Journal of Orthopaedic Trauma·Ramsey C KinneyTimothy Ganey
Sep 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S IjiriK Notoya
Dec 1, 1992·Journal of Periodontology·J T MellonigM P Moyer
Oct 1, 1993·Unfallchirurgie·J H Kühne, H J Refior
Oct 19, 2006·Expert Opinion on Drug Safety·Haralampos T H Dinopoulos, Peter V Giannoudis
Jan 26, 2017·Médecine sciences : M/S·Fabienne JordanaPierre Weiss
Jul 14, 2001·Clinical Orthopaedics and Related Research·S D FerreiraR M Wilkins
Jul 1, 1992·Veterinary Surgery : VS·A L JohnsonD J Schaeffer
Jun 17, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kathy TraianedesDavid Knaack
May 29, 1998·Acta Orthopaedica Scandinavica·P Aspenberg, S B Lindqvist
Nov 1, 1992·Journal of Biomedical Materials Research·V L KudrykJ O Hollinger
Jan 26, 1999·Clinical Orthopaedics and Related Research·S Stevenson
Apr 9, 2002·Clinical Orthopaedics and Related Research·Hisashi IwataThomas W Bauer
Mar 22, 2014·World Journal of Orthopedics·Konstantinos TilkeridisGeorgios I Drosos
Aug 12, 2017·Cell and Tissue Banking·Abigail PhippsEvangelia Chnari
Oct 16, 2015·Clinical Orthopaedics and Related Research·Anowarul IslamOzan Akkus
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Peter G Whang, Jeffrey C Wang
Apr 17, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Nobuhiro KakuTakehiko Torisu
Oct 1, 1993·Biomaterials·M J DohertyD J Wilson
Sep 3, 1999·The Orthopedic Clinics of North America·S Stevenson
Sep 3, 1999·The Orthopedic Clinics of North America·T BoyceN Scarborough
Nov 18, 2005·The Spine Journal : Official Journal of the North American Spine Society·Kenneth J H LeeJeffrey C Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.