PMID: 9436155Jan 22, 1998Paper

Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
H NeuenschwanderP F Kador

Abstract

The onset and progression of retinal vascular changes associated with early diabetic retinopathy has been delayed in beagles fed 30% galactose diet for 38 months by treatment with the aldose reductase inhibitor M79175 (2-methyl-6-fluoro-spirochroman-4-5'- imidazolidine-2',4'-dione). Forty 9-month old male beagles were fed a daily diet containing either 30% non-nutrient filler or 30% galactose. One group of galactose-fed dogs was untreated while the others received M79175 at an average group dose of either 10 or 16 mg/kg/day. After 38 months one eye from 4 dogs from each group was enucleated and the isolated retinal vasculatures were objectively evaluated using an Olympus Cue-3 color image analysis system. Measurements of endothelium/pericyte (E/P) ratios, pericyte ghosts/1000 cells, pericytes and endothelial densities, and % acellularity per area and % acellularity per capillary length were conducted on a 0.1 mm square area surrounding the midpoints of 12 previously defined subregions. With the exception of endothelial densities which were not changed in galactose-fed dogs, M79175 treatment resulted in smaller changes in all parameters examined with the E/P ratio in dogs treated with 16 mg/kg/day M79175 not significantly differ...Continue Reading

References

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Nov 1, 1986·Current Eye Research·Y AkagiJ H Kinoshita
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Mar 1, 1964·Diabetes·H R HAUSLERJ CAMPBELL
Feb 1, 1965·Archives of Ophthalmology·R L ENGERMAN, J M BLOODWORTH

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Citations

Jan 22, 2000·Biochemical Pharmacology·K SugiyamaP F Kador
Sep 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·P F KadorK Sugiyama
Jan 5, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·M J LizakP F Kador
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorMilton Wyman
Nov 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jun MakitaPeter F Kador
Nov 26, 2002·The British Journal of Ophthalmology·N OishiY Akagi
Dec 20, 2012·PloS One·Peter F KadorKaren Blessing
Jun 2, 2010·International Journal of Molecular Medicine·Irina G ObrosovaCarl-David Agardh
Apr 20, 2004·Veterinary Ophthalmology·Dolores J TakemotoLynn M Wagner
Mar 4, 2011·Veterinary Ophthalmology·Kenneth L AbramsSusan Elliott
Jan 12, 2005·Experimental Eye Research·G SunP F Kador
Jun 27, 2006·Experimental Eye Research·Carol B TorisPeter F Kador
Apr 23, 2016·Progress in Retinal and Eye Research·Peter F KadorPeter J Oates
Jul 31, 2019·Ophthalmic Research·Timothy S KernLois E H Smith

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