Dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands

Chemotherapy
D ChattopadhyayS K Bhattacharya

Abstract

The methanol extract of Ophirrhiza nicobarica, Alstonia macrophylla and Mallotus peltatus, ethnomedicines of Little Andaman, were investigated for antiinfective, antiinflammatory and antioxidant activities. Toxicity was determined in cells and in an animal model. Antiviral, antibacterial and antifungal activity was determined by plaque reduction, disc diffusion and agar dilution methods. The antiinflammatory and antioxidant activities were also studied. O. nicobarica at 300 microg ml(-1) showed anti-HSV activity while M. peltatus and A. macrophylla showed antibacterial activity at 64-1,000 microg ml(-1). Both extracts showed significant dose-dependent antiinflammatory and antioxidant activity at nontoxic concentrations. The alkaloid, flavonoid and beta-sitosterol isolated from bioactive parts had a dose-dependent therapeutic efficacy, justifying their use. Further study is required to know the mechanism of action.

References

Aug 1, 1995·Natural Product Reports· Atta-ur-Rahman, M I Choudhary
Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·D ChattopadhyayR Bhadra
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Apr 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A RussoA Vanella
Aug 3, 2001·Journal of Ethnopharmacology·D ChattopadhyayA B Mandal
Dec 19, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G ArunachalamS C Mandal

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Citations

Jun 1, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chattopadhyay DebprasadChakraborti Sekhar
Feb 18, 2021·Journal of Evidence-based Integrative Medicine·Anna GarberChris Pickrell
May 26, 2009·New Biotechnology·Debprasad ChattopadhyayMahmud Tareq Hassan Khan

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