Dose-dependent variations in blood flow evaluation of canine nerve, nerve graft, tendon, and ligament tissue by the radiolabeled-microsphere technique

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K RiggiD M Ilstrup

Abstract

This study evaluates the dose-dependent accuracy of the radionuclide-labeled microsphere technique for blood flow evaluation in nerve, tendon, and ligament. In eight dogs, blood flows were determined for nerve, nerve graft, tendon, and ligament tissue by simultaneous injection of high- and low-dose microspheres with different radiolabels. The results demonstrated no significant differences in blood flow as measured from the small number of microspheres (less than 400) and the high number (more than 400) for nerve and tendon tissue. For nerve tissue, microsphere counts of 50 to 100, 100 to 200, 200 to 300, and more than 300 produced mean percentage errors of 12.74% (n = 5, SEM = 4.52), 5.45% (n = 13, SEM = 1.22), 10.22% (n = 6, SEM = 4.37), and 17.08% (n = 12, SEM = 3.30), respectively. For tendon tissue, the same microsphere subdivisions had mean percentage errors of 7.47% (n = 4, SEM = 2.66), 3.63% (n = 6, SEM = 1.34), 15.54% (n = 4, SEM = 4.43), and 12.91% (n = 1), respectively. For ligament tissue, percentage errors were consistently higher; microsphere counts of 30 to 100, 100 to 200, and 200 to 300 produced mean errors of 20.14% (n = 4, SEM = 6.38), 18.66% (n = 4, SEM = 6.24), and 25.78% (n = 2, SEM = 1.97), respectively. ...Continue Reading

References

Jul 1, 1978·Journal of Periodontal Research·M L KaplanP Goldhaber
Jan 1, 1979·The American Journal of Physiology·T Akiyama, H A Fozzard
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Mar 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J J Siegert, M B Wood
Jan 1, 1987·Plastic and Reconstructive Surgery·J Fisher, M B Wood
May 1, 1974·Investigative Radiology·R J BartrumN K Hollenberg
Jan 1, 1974·Clinical and Experimental Pharmacology & Physiology·J R Parratt, E Winslow
Jul 1, 1973·Journal of Applied Physiology·J P ArchieE L Carlson
Dec 30, 1967·Nature·R H PhibbsJ M Neutze
Aug 1, 1968·The American Journal of Physiology·J M NeutzeA M Rudolph
Nov 1, 1969·Investigative Radiology·H N WagnerJ P Ryan
Feb 1, 1971·Circulation Research·L M SlotkoffG M Eisner
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Mar 1, 1966·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·D E TowT Migita
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S A RiggsP J Kelly
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A WeidmanD M Ilstrup
Oct 1, 1984·Journal of Reconstructive Microsurgery·C R Settergren, M B Wood
Jan 1, 1980·Calcified Tissue International·M A Morris, P J Kelly
Jan 1, 1963·The American Journal of Physiology·H L STONEA C GUYTON

Citations

Aug 2, 2003·BMC Clinical Pharmacology·David G Levitt
Apr 29, 2016·Upsala Journal of Medical Sciences·Leif JanssonPer-Ola Carlsson
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R C BrayJ V Tyberg
Jan 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Y MakiJ C Firrell
Jan 1, 1995·Acta Oto-laryngologica·T NakashimaN Yanagita

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