Dose determinations for waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl and related pharmacokinetics in two species of trout (Salmo gairdneri and Salvelinus fontinalis): a mass-balance approach

Toxicology and Applied Pharmacology
J M McKim, E M Heath

Abstract

A mass-balance study was undertaken to evaluate the accuracy of dose determinations of waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl (TCB) made on transected brook trout (Salvelinus fontinalis) and rainbow trout (Salmo gairdneri) and to determine any pharmacokinetic differences between the two species. The total calculated [14C]TCB absorbed by brook (17.8 micrograms) and rainbow (24.5 micrograms) trout was compared to the actual body burden measurements of [14C]TCB for brook (17.4 micrograms) and rainbow (25.6 micrograms) trout; the latter measurements also included excretory losses through the urine, feces, and across the gill surface. Approximately 1% of the total dose was excreted of which 75% was in the urine and 25% in the feces. The agreement between the whole body burden measurements of [14C]TCB and the total calculated micrograms of [14C]TCB absorbed was within 10% in both species. Mass-balance measurements were converted to dose by dividing by fish weight. Mean calculated and measured doses were 31.4 and 30.4 micrograms/kg/48 hr for brook trout and 32.3 and 33.6 micrograms/kg/48 hr for rainbow trout. No species differences were seen in either calculated or measured doses or in total radioactivity excreted. Respiratory ...Continue Reading

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Citations

May 1, 1990·Archives of Environmental Contamination and Toxicology·J Mallatt, C Stinson
Mar 16, 2013·Environmental Science and Pollution Research International·Margaret O James, Kevin M Kleinow
Jan 1, 1984·Drug Metabolism Reviews·R L BinderJ J Lech
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Nov 15, 2018·Environmental Science and Pollution Research International·Md Habibullah-Al-MamunShigeki Masunaga
Dec 1, 1992·Ecotoxicology and Environmental Safety·P PärtK Havaste
Feb 1, 1990·Ecotoxicology and Environmental Safety·P Pärt

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