Dose effect of gestational ethanol exposure on placentation and fetal growth

Placenta
F GundoganSuzanne M de la Monte

Abstract

Prenatal ethanol exposure compromises fetal growth by impairing placentation. Invasive trophoblastic cells, which mediate placentation, express the insulin-IGF regulated gene, aspartyl-asparaginyl β-hydroxylase (ASPH), which has a critical role in cell motility and invasion. The aims of this study were to characterize effects of ethanol on trophoblastic cell motility, and assess ethanol dose-dependent impairments in placentation and fetal development. Pregnant Long Evans dams were fed with isocaloric liquid diets containing 0%, 8%, 18% or 37% ethanol (caloric content) from gestation day (GD) 6 to GD18. Fetal development, placental morphology, density of invasive trophoblasts at the mesometrial triangle, as well as placental and mesometrial ASPH and Notch-1 protein expression were evaluated. Directional motility of control and ethanol-exposed HTR-8/SVneo cells was assessed by ATP Luminescence-Based assay. Severity of fetal growth impairment correlated with increasing doses of ethanol. Ethanol exposure produced dose-dependent alterations in branching morphogenesis at the labyrinthine zone, and inhibited physiological transformation of maternal arteries. ASPH and Notch-1 protein expression levels were reduced, corresponding with i...Continue Reading

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Citations

Jul 4, 2018·The American Journal of Tropical Medicine and Hygiene·Emily A McDonaldJennifer F Friedman
Mar 6, 2019·Life Science Alliance·Alexander M TsengUNKNOWN Collaborative Initiative on Fetal Alcohol Spectrum Disorders
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Jan 17, 2021·International Journal of Molecular Sciences·Laura Almeida-ToledanoMaría Dolores Gómez-Roig
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Oct 27, 2021·Alcoholism, Clinical and Experimental Research·Sze Ting Cecilia KwanSandra M Mooney

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