PMID: 9186281Jan 1, 1997Paper

Dose-effect relationships of prostaglandin E1 in severe endstage chronic heart failure

Japanese Heart Journal
B Stanek, R Pacher

Abstract

Prostaglandin E1 is a potent vasodilator in severe chronic heart failure. To evaluate the time sequence and magnitude of prostaglandin E1's hemodynamic effects a dose finding study was performed in 24 patients. Right heart catheterization was performed and prostaglandin E1 was administered via a central venous line in incremental doses of 2.5, 10, 20, 30 and 40 ng/kg/min, each dose, lasting 15 min before hemodynamic evaluation. The first significant change was a approximately 20% decrease in systemic vascular resistance index accompanied by a approximately 18% increase in cardiac index at an infusion rate of 2.5 ng/kg/min of prostaglandin E1, which was sustained at 5 ng/kg/min in all patients. A dose response-curve with cumulative doses ranging from 2.5 to 25 ng/kg/min of prostaglandin E1 was established in a subset of 14 patients due to 10 drop-outs at lower dosages. At 2.5 and 5 ng/kg/min of prostaglandin E1, cardiac index increased by 18% (p < 0.05) and peripheral resistance decreased by 18% (p < 0.01). These changes were sustained up to a maximal dose of 25 ng/kg/min, which was tolerated by all patients in this group. At 15 and 20 ng/kg/min of prostaglandin E1 a significant decrease in blood pressure of -4 mmHg (p < 0.05) w...Continue Reading

Citations

Apr 1, 1997·Prostaglandins·R PacherH Sinzinger
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeanette Strametz-JuranekBrigitte Stanek
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B StanekR Pacher
Nov 26, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Santiago G MorenoNicola J Cooper
Jul 17, 2016·Prostaglandins & Other Lipid Mediators·Jin-Dan WuJian-Hua Ma

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