Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation

Bioengineering & Translational Medicine
Herman HauWojciech Chrzanowski

Abstract

Despite major advances in the field of radiotherapy, healthy tissue damage continues to constrain the dose that can be prescribed in cancer therapy. Gold nanoparticles (GNPs) have been proposed as a solution to minimize radiation-associated toxicities by enhancing the radiation dose delivered locally to tumor cells. In the current study, we investigated the application of third-generation GNPs in two-dimensional (2D) and three-dimensional (3D) cell cultures and whether there is synergy between the nanoparticles and kilo- or mega-voltage radiation to cause augmented cytotoxicity. The 10-nm GNPs were found to be nontoxic in both 2D and 3D in vitro cultures of colon cancer cells at concentrations of up to 10-25 µg/ml. There was a significant increase in cell survival fraction reduction following exposure to 1 Gy of kilo-voltage (18.3%) and 2 Gy of mega-voltage (35.3%) radiation when the cells were incubated with 50 µg/ml of GNPs. The biocompatibility of the GNPs combined with their substantial synergy with radiation encourages further investigations into their application in targeted cancer treatment.

References

Jul 22, 2004·Bioconjugate Chemistry·Catherine M GoodmanVincent M Rotello
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Nov 3, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ravi ShuklaMurali Sastry
Apr 5, 2007·Nature Protocols·Nicolaas A P FrankenChris van Bree
Oct 30, 2007·Small·Yu PanWilli Jahnen-Dechent
May 27, 2008·Advanced Drug Delivery Reviews·Resham Bhattacharya, Priyabrata Mukherjee
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·James F HainfeldHenry M Smilowitz
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephanie E A GrattonJoseph M DeSimone
Jan 17, 2009·Cancer Research·Philip P Connell, Samuel Hellman
Feb 20, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Nezahat Hunter, Colin R Muirhead
Mar 6, 2009·Small·Jungwoo LeeNicholas A Kotov
Oct 22, 2009·Small·Ayush Verma, Francesco Stellacci
Jan 22, 2010·Physics in Medicine and Biology·Chi-Jen LiuG Margaritondo
Jun 4, 2010·Radiation Research·Devika B ChithraniDavid A Jaffray
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Suneil JainDavid G Hirst
Jun 22, 2011·Australasian Physical & Engineering Sciences in Medicine·M D E PotterD R McKenzie
Mar 29, 2012·Australasian Physical & Engineering Sciences in Medicine·Elizabeth Claridge MackonisDavid R McKenzie
Dec 19, 2012·Toxicology Letters·Rosella CoradeghiniFrançois Rossi
Jan 8, 2013·Expert Opinion on Drug Delivery·Deepak KumarVinay Pandit
Dec 10, 2013·Journal of Hazardous Materials·Pin Ju ChuehShow-Mei Chuang
Jan 1, 2010·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Asghar Mesbahi

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Citations

Mar 6, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Zhino MoradiZhaleh Behrouzkia
Jan 16, 2020·International Journal of Molecular Sciences·Farasat KazmiRobert Carlisle
Jun 30, 2016·Bioengineering & Translational Medicine·Paolo Decuzzi, Samir Mitragotri
Jun 16, 2017·Journal of Cellular Physiology·Eddy-Tim VerjansLiliane Schoofs
Jul 13, 2017·PloS One·Sophie GrelletJon P Golding
Dec 3, 2020·International Journal of Nanomedicine·Yao ChenJingbo Wu
Apr 24, 2021·Medicinal Research Reviews·Firdos A KhanFaheem H Pottoo
Dec 28, 2017·Analytical Chemistry·Tomasz P Wrobel, Rohit Bhargava

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Methods Mentioned

BETA
electrophoretic light scattering
AFM

Software Mentioned

Inbuilt
Prism
n3D
MATLAB

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