Dose escalation of paclitaxel with high-dose cyclophosphamide, with analysis of progenitor-cell mobilization and hematologic support of advanced ovarian cancer patients receiving rapidly sequenced high-dose carboplatin/cyclophosphamide courses

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
D FennellyW Hoskins

Abstract

We commenced a phase I study of escalating dose Taxol (paclitaxel; Bristol-Myers Squibb Co, Wallingford, CT) in addition to cyclophosphamide, to assess its impact on both antitumor efficacy and mobilization of peripheral-blood progenitor cells (PBP). Induction therapy consisted of two cycles of cyclophosphamide 3.0 g/m2 plus escalating-dose Taxol (dose levels I to IV, 150, 200, 250, and 300 mg/m2, respectively) in cohorts of three, plus filgrastim granulocyte colony-stimulating factor [G-CSF]) and leukaphereses to harvest PBP, followed by four courses of rapidly cycled carboplatin and cyclophosphamide (1,000 and 1,500 mg/m2 per course, respectively), for which hematopoietic rescue was achieved with PBP. Sixteen patients completed all planned cycles of Taxol/cyclophosphamide. Fifty-four cycles of carboplatin/cyclophosphamide were given and rescued with PBP. The median interval between treatments for Taxol/cyclophosphamide courses was 14 days (range, 13 to 21). Twelve patients completed all planned cycles of carboplatin/cyclophosphamide. The median inter-treatment interval for carboplatin/cyclophosphamide courses when rescue was achieved with Taxol/cyclophosphamide-primed PBP was 17 days (range, 14 to 25). The median number of da...Continue Reading

Citations

Feb 15, 1997·Medizinische Klinik·F Hartmann, M Pfreundschuh
Jun 14, 2003·Journal of Hematotherapy & Stem Cell Research·John O OjeifoKenneth R Meehan
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jonathan A Ledermann
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·A GollerkeriB A Burtness
Sep 19, 2006·Bone Marrow Transplantation·N FrickhofenUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie (AGO)
May 2, 2002·Journal of Hematotherapy & Stem Cell Research·Kenneth R MeehanMarc E Lippman
Apr 1, 1996·Annals of Medicine·K Hoekman, J B Vermorken
Apr 11, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J A Ledermann

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