Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma

Cancer Medicine
Dalia ElganainyEugene J Koay

Abstract

To evaluate the effect of escalated dose radiation therapy (EDR, defined as doses >50.4 Gy in 28 fractions [59.5 Gy BED]) on overall survival (OS), freedom from local progression (FFLP), and freedom from distant progression (FFDP) of patients with unresectable extrahepatic cholangiocarcinoma (EHCC). A consecutive cohort of 80 patients who underwent radiotherapy for unresectable EHCC from 2001 to 2015 was identified. Demographic, tumor, treatment, toxicity, and laboratory variables were collected. The maximal RT doses ranged from 30 to 75 Gy (median 50.4 Gy, at 1.8-4.5 Gy/fraction). Gross tumor volume (GTV) coverage by maximal dose in EDR group ranged from 38% to 100%. Kaplan-Meier method was used to estimate OS, FFLP, and FFDP. Univariate and multivariate Cox regression models were analyzed. After radiotherapy, median OS, FFLP, and FFDP were 18.7, 22.6, and 24.3 months, respectively. There was no significant difference in OS or FFLP between patients who received EDR to portions of the GTV and patients who did not. On multivariate analysis, bigger GTV, age, and ECOG performance status were independently associated with shorter OS. Local progression on chemotherapy prior to RT was independently associated with shorter FFLP. High ...Continue Reading

References

Oct 1, 1996·Annals of Surgery·A NakeebJ L Cameron
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·M L FooS J Buskirk
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneNora A Janjan
Oct 12, 2002·Gut·S A KhanUNKNOWN British Society of Gastroenterology
May 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael T MilanoRuth Heimann
Dec 14, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas B BrunnerRolf Sauer
Jun 28, 2005·International Journal of Radiation Oncology, Biology, Physics·Jolie RingashLaura Dawson
Oct 3, 2006·International Journal of Radiation Oncology, Biology, Physics·Merav A Ben-DavidEdgar Ben-Josef
Oct 26, 2006·Radiation Oncology·Prajnan DasChristopher H Crane
Jul 21, 2007·Frontiers of Radiation Therapy and Oncology·Mojgan TaremiLaura A Dawson
Jan 23, 2008·Journal of Clinical Gastroenterology·Patrick Yachimski, Daniel S Pratt
Feb 10, 2009·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaJames M Metz
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 25, 2010·International Journal of Radiation Oncology, Biology, Physics·A Paiman GhafooriBrian G Czito
Dec 15, 2010·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Matthew M PoppeSalma K Jabbour
Mar 19, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M G McNamaraJ J Knox
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
May 13, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edgar Ben-JosefCharles D Blanke
Oct 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Randa TaoChristopher H Crane
Feb 13, 2016·International Journal of Radiation Oncology, Biology, Physics·Aaron T WildSusannah G Ellsworth
Sep 30, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eliza W BealCarl R Schmidt
Nov 9, 2017·Advances in Radiation Oncology·Lauren E ColbertCullen M Taniguchi

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Citations

Jan 1, 2021·Frontiers in Oncology·Eleni GkikaThomas B Brunner
Jun 17, 2021·PloS One·Minji KohJong Hoon Kim

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Methods Mentioned

BETA
surgical resection

Software Mentioned

JMP pro

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