Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer

International Journal of Radiation Oncology, Biology, Physics
Jun-Etsu MizoeOrganizing Committee for the Working Group for Head-And-Neck Cancer

Abstract

To evaluate the toxicity and efficacy of carbon ion radiotherapy for head-and-neck cancer in a Phase I/II dose escalation clinical trial. Between June 1994 and January 1997, 36 patients with locally advanced, histologically proven, and new or recurrent cancer of the head and neck were treated with carbon ions. A dose escalation study was conducted, delivering 18 fractions through 6 weeks for 17 patients (Group A) and 16 fractions through 4 weeks for 19 patients (Group B). Eligibility and ineligibility criteria were the same in both groups. The dosages were escalated in increments of 10% after careful observation of at least 3 patients treated with the same dosages. The endpoints of the study were a Grade 3 reaction of the skin and the mucous membrane or local control of the tumors. Follow-up time ranged from 77 to 108 months with a median of 90 months. Grade 3 acute reaction of the skin was detected in 1 of the 2 patients in Group A who were treated with 70.2 GyE/18 fractions/6 weeks. In Group B, Grade 3 acute skin reaction was detected in 20% (1/5), 27% (2/11), and 67% (2/3) patients treated with 52.8 GyE, 57.6 GyE, and 64.0 GyE through 16 fractions for 4 weeks, respectively. There was only 1 patient with a Grade 3 acute react...Continue Reading

References

Jul 1, 1992·Critical Reviews in Oncology/hematology·T W Griffin
Jan 1, 1992·Radiation and Environmental Biophysics·E A Blakely
Feb 1, 1987·International Journal of Radiation Oncology, Biology, Physics·W DuncanJ R Williams
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J R Castro, M M Reimers
Dec 1, 1984·International Journal of Radiation Oncology, Biology, Physics·T W GriffinG E Laramore
Dec 1, 1982·International Journal of Radiation Oncology, Biology, Physics·C A TobiasT C Yang
Mar 1, 1995·Radiation and Environmental Biophysics·J R Castro
Jan 1, 1994·Acta Oncologica·H Svensson, T Landberg
Feb 7, 2001·International Journal of Radiation Biology·K AndoM Urano

❮ Previous
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Citations

May 17, 2008·HNO·F SterzingJ Debus
Mar 3, 2010·International Journal of Clinical Oncology·Pierre HeudelPascal Pommier
Mar 20, 2012·International Journal of Clinical Oncology·Tadashi Kamada
May 11, 2012·Frontiers of Medicine·Guo-Liang Jiang
Jan 17, 2014·Journal of Maxillofacial and Oral Surgery·Shinnosuke NakamuraToshiro Tagawa
Jul 17, 2012·Japanese Journal of Clinical Oncology·Hirohiko Tsujii, Tadashi Kamada
Oct 9, 2009·Radiation Protection Dosimetry·A FukumuraS Yonai
Apr 18, 2009·Current Opinion in Oncology·George E Laramore
Apr 25, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T OhnoH Tsujii
Jun 16, 2012·Journal of Oncology·Upendra ParvathaneniJay J Liao
Apr 7, 2011·Radiation Oncology·Alexandra D JensenMarc W Münter
Mar 18, 2006·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Riwa KishimotoHirohiko Tsujii
Nov 5, 2013·Gynecologic Oncology·Masaru WakatsukiUNKNOWN Working Group of the Gynecological Tumor
Dec 25, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A Moore
Mar 24, 2011·The British Journal of Radiology·A D JensenJ Debus
Mar 25, 2008·The Bulletin of Tokyo Dental College·Nobuharu YamamotoJun-Etsu Mizoe
May 13, 2009·Acta neurochirurgica·Satoshi TakahashiJun-Etsu Mizoe
Apr 4, 2008·International Journal of Radiation Biology·Yoshitaka MatsumotoTakashi Imai
Jul 13, 2011·International Journal of Radiation Oncology, Biology, Physics·Keiichi JinguUNKNOWN Organizing Committee for the Working Group for Head-and-Neck Cancer
Oct 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Shinichiro MoriMasayuki Baba
Jan 29, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andrea PeetersPhilippe Lambin
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Mira MaaloufClaire Rodriguez-Lafrasse
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Tomoaki TamakiTakashi Imai
Dec 3, 2008·International Journal of Radiation Oncology, Biology, Physics·Takeshi YanagiHirohiko Tsujii
Aug 30, 2008·International Journal of Radiation Oncology, Biology, Physics·Indira MadaniWilfried De Neve
Aug 13, 2008·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Marta MumotJulian Malicki
Jun 3, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kazuaki FushimiHideki Tanzawa
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Michael BeuveClaire Rodriguez-Lafrasse
May 16, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mark LodgeTom Jefferson
Jun 14, 2012·International Journal of Otolaryngology·Marco Cianchetti, Maurizio Amichetti
Nov 20, 2012·The Laryngoscope·Richie Chiu-Lung ChanWilliam Ignace Wei

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