PMID: 9635695Jul 4, 1998Paper

Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions

International Journal of Radiation Oncology, Biology, Physics
G E HanksM A Hunt

Abstract

To report the 5-year outcomes of dose escalation with 3D conformal treatment (3DCRT) of prostate cancer. Two hundred thirty-two consecutive patients were treated with 3DCRT alone between 6/89 and 10/92 with ICRU reporting point dose that increased from 63 to 79 Gy. The median follow-up was 60 months, and any patient free of clinical or biochemical evidence of disease was termed bNED. Biochemical failure was defined as prostate-specific antigen (PSA) rising on two consecutive recordings and exceeding 1.5 ng/ml. Morbidity was reported by the Radiation Therapy Oncology Group (RTOG) scale, the Late Effects Normal Tissue (LENT) scale, and a Fox Chase modification of the latter (FC-LENT). All patients were treated with a four-field technique with a 1 cm clinical target volume (CTV) to planning target volume (PTV) margin to the prostate or prostate boost; the CTV and gross tumor volume (GTV) were the same. Actuarial rates of outcome were calculated by Kaplan-Meier and cumulative incidence methods and compared using the log rank and Gray's test statistic, respectively. Cox regression models were used to establish prognostic factors predictive of the various measures of outcome. Five-year Kaplan-Meier bNED rates were utilized by dose gr...Continue Reading

References

Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H M SandlerA S Lichter
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G E Hanks
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G E Hanks
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A PollackI I Rosen
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J D FormanC Orton
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·G E HanksL R Coia
Apr 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A L HanlonG E Hanks
Jul 1, 1997·Urology·G E HanksB Movsas
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·N Fukunaga-JohnsonA S Lichter
Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J P LattanziG E Hanks
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·T TeshimaT E Schultheiss

❮ Previous
Next ❯

Citations

Nov 20, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tetsuo Akimoto
Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·J G RajendranD A Mankoff
May 12, 2005·Journal of Cancer Research and Clinical Oncology·U GanswindtC Belka
Sep 19, 2008·Current Gastroenterology Reports·Mohammed A Qadeer, John J Vargo
May 21, 2003·Current Urology Reports·Andrew Bayley, Mary K Gospodarowicz
Apr 6, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L Wisser
Nov 11, 2003·Critical Reviews in Oncology/hematology·Sergio VillaPatrizia Olmi
Mar 17, 2004·Current Problems in Cancer·Natia EsiashviliJerome Landry
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Scott G Williams
Jun 1, 2005·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Lu WangCharlie C M Ma
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Carlo GrecoRoberto Orecchia
Apr 7, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thomas MartinNikolaos Zamboglou
Jan 14, 1999·Urology·B MovsasG E Hanks
Mar 4, 2000·Urology·J C Blasko
Mar 28, 2003·Lancet·Ashesh B Jani, Samuel Hellman
May 2, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P NickersJ Deneufbourg
May 2, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J W MensH A Langendijk
Dec 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D C Beyer, D G Brachman
Dec 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J C BlaskoW Cavanagh
Apr 11, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D C WeberR Miralbell
Nov 3, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A J NederveenJ J Lagendijk
Nov 3, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J WuC Catton
Apr 9, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B C John ChoBen J Mijnheer
Jun 18, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sabine LevegrünC Clifton Ling
Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Per FranssonAnders Widmark
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael BrundageUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Genitourinary Cancer Disease Site Group
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joost J NuyttensAndrew T Turrisi
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John Armstrong
Mar 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniela CorlettoClaudio Fiorino
May 14, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laura HappersettGerald J Kutcher
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurent SalomonJean-Leon Lagrange
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rakesh R PatelMark A Ritter
Nov 5, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·George RodriguesGerard Morton
Mar 3, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C C Parker, D P Dearnaley
Jun 21, 2002·European Urology·J A BogersA G Visser
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·G O De MeerleerW De Neve

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.