Dose estimation and surveillance of mechanical loading interventions for bone loss after spinal cord injury.

Physical Therapy
S Dudley-Javoroski, R K Shields

Abstract

The interpretation of the results of previous anti-osteoporosis interventions after spinal cord injury (SCI) is undermined by incomplete information about the intervention dose or patient adherence to dose requirements. Rehabilitation research as a whole traditionally has struggled with these same issues. The purpose of this case report is to offer proof of the concepts that careful dose selection and surveillance of patient adherence should be integral components in rehabilitation interventions. A 21-year-old man with T4 complete paraplegia (7 weeks) enrolled in a unilateral soleus muscle electrical stimulation protocol. Compressive loads applied to the tibia approximated 1.4 times body weight. Over 4.8 years of home-based training, data logging software provided surveillance of adherence. Soleus muscle torque and fatigue index adaptations to training as well as bone mineral density (BMD) adaptations in the distal tibia were measured. The patient performed nearly 8,000 soleus muscle contractions per month, with occasional fluctuations. Adherence tracking permitted intervention when adherence fell below acceptable values. The soleus muscle torque and fatigue index increased rapidly in response to training. The BMD of the untrai...Continue Reading

Associated Clinical Trials

References

Nov 1, 1979·Paraplegia·A ChantraineP Schinas
May 1, 1978·Paraplegia·A Chantraine
Mar 1, 1990·Archives of Physical Medicine and Rehabilitation·E M LeedsB A Green
Jan 1, 1996·American Journal of Physical Medicine & Rehabilitation·K K BeDellC F Kunkel
Sep 28, 1998·Archives of Physical Medicine and Rehabilitation·A HartkoppF Biering-Sørensen
Jan 14, 1999·Journal of Applied Physiology·M J CastroG A Dudley
May 8, 2002·Muscle & Nerve·Stephen D R HarridgeMichael Kjaer
Sep 5, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·UNKNOWN Task Force of The Canadian Society of Clinical Neurophysiologists
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Apr 26, 2003·European Journal of Clinical Investigation·P EserE Stüssi
Dec 25, 2003·Muscle & Nerve·Regina M CrameriAdele Weston
Apr 13, 2005·Disability and Rehabilitation·Richard K Shields, Shauna Dudley-Javoroski
Jan 6, 2006·Disability and Rehabilitation·Shauna Dudley-Javoroski, Richard K Shields
Jan 13, 2006·Journal of Neurophysiology·Richard K Shields, Shauna Dudley-Javoroski
Jul 11, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Andreas Ludwig ReiterHans Juergen Gerner
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pia PogodaMichael Amling
Oct 7, 2006·Archives of Physical Medicine and Rehabilitation·Richard K ShieldsJacquelyn M Ruen
Feb 22, 2007·Neurorehabilitation and Neural Repair·Richard K Shields, Shauna Dudley-Javoroski
Apr 19, 2007·Calcified Tissue International·M S Patel, F Elefteriou
Mar 1, 1997·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·R K Shields, Y J Chang
Feb 15, 2013·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields

❮ Previous
Next ❯

Citations

Aug 27, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Dudley-Javoroski, R K Shields
Dec 22, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Dudley-JavoroskiR K Shields
May 12, 2012·European Journal of Applied Physiology·Alfredo Arija-BlázquezJosé Florensa-Vila
Nov 20, 2012·Journal of Neurotrauma·Felicitas WirthEckhard Schönau
Mar 13, 2013·American Journal of Physical Medicine & Rehabilitation·Ariane ZamarioliAntonio C Shimano
Feb 15, 2013·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields
Jul 3, 2013·The Journal of Spinal Cord Medicine·Shauna Dudley-Javoroski, Richard K Shields
Feb 13, 2016·Cell Death and Differentiation·Q ChenY Shi
Jun 29, 2011·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Shuo-Hsiu ChangRichard K Shields
Dec 15, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Suzanne L GroahInger Ljungberg
Aug 31, 2010·Ultrasound in Medicine & Biology·Shauna Dudley-JavoroskiRichard K Shields
Apr 1, 2010·Biomedical Signal Processing and Control·Zhijun CaiRichard K Shields
Jul 28, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Maureen J Devlin
Jan 29, 2011·Archives of Physical Medicine and Rehabilitation·Shauna Dudley-JavoroskiRichard K Shields
Oct 5, 2013·The Journal of Spinal Cord Medicine·Alfredo Arija-BlázquezJosé Florensa-Vila
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Maureen J Devlin, Clifford J Rosen
Mar 16, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shih-Chiao Tseng, Richard K Shields
Nov 22, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shih-Chiao Tseng, Richard K Shields
Sep 12, 2019·Scientific Reports·Ioannis D ZouliasWilliam Holderbaum
May 13, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Saeed Soleyman-JahiVafa Rahimi-Movaghar
Nov 16, 2017·Journal of Motor Behavior·Shih-Chiao Tseng, Richard K Shields

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.