PMID: 2499203May 1, 1989Paper

Dose-finding study for praziquantel therapy of Schistosoma haematobium in Coast Province, Kenya

The American Journal of Tropical Medicine and Hygiene
C H KingA A Mahmoud

Abstract

To assess the efficacy of low dose praziquantel regimens in comparison with standard 40 mg/kg dosing in the treatment of urinary schistosomiasis, a random allocation dose-finding trial was performed in children and adults from a Schistosoma haematobium endemic region in Coast Province, Kenya. Following an initial screening, 280 individuals with greater than or equal to 50 eggs/10 ml urine were randomly assigned to receive either 10, 20, 30, or 40 mg/kg of the drug in a single oral dose. Two to three months later, cure rates of 26%, 68%, 78%, and 84% were found for the 10, 20, 30, and 40 mg/kg doses, respectively. The results of 10 mg/kg oral dosing were significantly worse than for all other doses in terms of cure rate and of post-treatment prevalence of morbidity. The 40 mg/kg dosing resulted in a significantly higher cure rate than the 20 mg/kg doses; nevertheless, there was no significant difference between 20 mg/kg and 40 mg/kg doses in terms of mean post-treatment intensity of infection or post-treatment prevalence of hematuria or proteinuria. For large-scale control programs, oral 20 mg/kg praziquantel therapy for urinary schistosomiasis may prove as effective as the standard oral 40 mg/kg dosing for control of infection-...Continue Reading

Citations

Aug 8, 2014·The Cochrane Database of Systematic Reviews·Christine V KramerPiero L Olliaro
Aug 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sanaa S BotrosRobert Bergquist
Mar 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·A HallD Bundy

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