Dose modeling of noninvasive image-guided breast brachytherapy in comparison to electron beam boost and three-dimensional conformal accelerated partial breast irradiation

International Journal of Radiation Oncology, Biology, Physics
Shirin SioshansiDavid E Wazer

Abstract

To perform dose modeling of a noninvasive image-guided breast brachytherapy (NIIGBB) for comparison to electrons and 3DCRT. The novel technology used in this study is a mammography-based, noninvasive breast brachytherapy system whereby the treatment applicators are centered on the planning target volume (PTV) to direct (192)Ir emissions along orthogonal axes. To date, three-dimensional dose modeling of NIIGBB has not been possible because of the limitations of conventional treatment planning systems (TPS) to model variable tissue deformation associated with breast compression. In this study, the TPS was adapted such that the NIIGBB dose distributions were modeled as a virtual point source. This dose calculation technique was applied to CT data from 8 patients imaged with the breast compressed between parallel plates in the cranial-caudal and medial-lateral axes. A dose-volume comparison was performed to simulated electron boost and 3DCRT APBI. The NIIGBB PTV was significantly reduced as compared with both electrons and 3DCRT. Electron boost plans had a lower D(min) than the NIIGBB technique but higher V(100), D(90), and D(50). With regard to PTV coverage for APBI, the only significant differences were minimally higher D(90), D(...Continue Reading

References

Oct 12, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·R KrishnamurthyA C Kushwaha
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Daniel M LandisJay R Harris

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Citations

Jan 10, 2012·ISRN Oncology·Susan HooverSunil Patel
Aug 6, 2011·Brachytherapy·Jaroslaw T Hepel, David E Wazer
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Subarna HamidDavid E Wazer
Jul 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Jaroslaw T HepelDavid E Wazer

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