Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma

Pediatric Blood & Cancer
Alexander A BoucherJames I Geller

Abstract

Hepatoblastoma can be associated with chronic kidney disease and genitourinary anomalies. Cisplatin is a key agent for treating hepatoblastoma but renal clearance and toxicity can limit its use in end-stage renal disease. We present pharmacokinetic data and clinical outcomes using cisplatin on hemodialysis for three patients with hepatoblastoma. All patients were initially treated with surgery and adjuvant cisplatin [1.67 mg/kg (2 patients) or 50 mg/m2 (1 patient)]. The patient treated with body surface area-based dosing had higher exposures and ototoxicity. Treating hepatoblastoma with cisplatin on hemodialysis using 1.67 mg/kg achieved clinical efficacy with minimal morbidity.

References

Mar 1, 1979·Clinical Pharmacology and Therapeutics·P E GormleyR Cysyk
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B PengD R Newell
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S Go, A A Adjei
Oct 16, 2001·European Journal of Clinical Pharmacology·B ErdlenbruchM Lakomek
May 21, 2004·British Journal of Clinical Pharmacology·Sail Urien, François Lokiec
Jul 20, 2004·Cancer Chemotherapy and Pharmacology·Saik UrienFrançois Lokiec
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael FroehnerManfred P Wirth
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Oct 23, 2009·The New England Journal of Medicine·Giorgio PerilongoPiotr Czauderna
Jan 20, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Judit SebestyenDouglas L Blowey
Nov 3, 2010·Journal of Pediatric Surgery·Merle KummerfeldGerhard Stuhldreier
May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Brian BecknellDavid S Hains
Dec 7, 2013·Journal of Pediatric Hematology/oncology·Yu-Tong ZhangJian Chang
Jun 18, 2014·American Journal of Medical Genetics. Part a·Rajkumar VenkatramaniJoshua D Schiffman

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Citations

Oct 6, 2020·Expert Opinion on Drug Metabolism & Toxicology·Maud MaillardEtienne Chatelut
Mar 30, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Qing TangZhengzhi Zou

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