Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid

Radiation and Environmental Biophysics
Sanny B KumarVijayta D Chadha

Abstract

The present study was undertaken to optimize the dose of lithium, with an aim to increase the retention of I-131 in the thyroid follicles while maintaining the euthyroid state. 24 female Wistar rats weighing 110 ± 20 g were segregated into four groups. Animals in group I were fed standard laboratory feed and water throughout the period of experimentation. Animals in group II, III and IV were additionally fed with lithium in the form of lithium carbonate orally, at a dose of 10 mg/kg body weight, 20 mg/kg body weight, 30 mg/kg body weight respectively. The dose of lithium was started 1 week prior to radioiodine administration and continued thereafter for another 8 days. After 7 days of lithium treatment, 0.48 MBq of carrier-free I-131 was injected intraperitoneally into each rat, of the four groups. I-131 thyroidal uptake and biokinetics, as well as serum TSH, T3, T4 levels were estimated in all the treatment groups. A significant increase in the thyroid and whole body counts was observed after 4 and 24 h of I-131 aministration in lithium treated rats, compared to control animals. An increase in thyroidal effective t1/2 and serum TSH levels, along with decrease in the levels of serum T3 and T4 was observed with a dose of 20 mg/k...Continue Reading

References

Mar 20, 1976·Lancet·J G TurnerT G Rogers
Aug 3, 1978·Biochimica Et Biophysica Acta·N BagchiR E Mack
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·M C GershengornJ Robbins
Nov 1, 1970·Endocrinology·S C BerensD L Murphy
Jul 1, 1970·The Journal of Clinical Investigation·S C BerensJ Wolff
Apr 8, 1970·Biochemical and Biophysical Research Communications·J WolffA B Jones
May 1, 1971·The Journal of Clinical Endocrinology and Metabolism·G N BurrowJ M Hershman
Dec 1, 1972·The Journal of Clinical Endocrinology and Metabolism·S W SpauldingJ M Himmelhoch
Sep 1, 1995·Clinical Pharmacokinetics·P R FinleyC A Peabody
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·J H Lazarus
Jul 5, 2002·Thyroid : Official Journal of the American Thyroid Association·C S BalR M Pandey
Nov 15, 2002·Advances in Therapy·Nurgul OzpoyrazEmel Kulan
Jun 6, 2006·The American Journal of Medicine·Marlene P Freeman, Scott A Freeman
Jan 9, 2007·The Journal of Clinical Endocrinology and Metabolism·David S Cooper
Nov 18, 2009·Thyroid : Official Journal of the American Thyroid Association·Giancarlo BasiliOrlando Goletti
Feb 9, 2013·Thyroid Research·Davis KibirigeRichard Ssekitoleko
Aug 12, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Peter LaurbergStine Linding Andersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.