Abstract
Mometasone furoate (MF; Schering-Plough, Madison, NJ), is a glucocorticoid with high local potency and low potential systemic availability. To compare the relative efficacy and safety of a new formulation of MF, coupled with a recently designed dry powder inhaler (DPI), in the treatment of patients with moderate persistent asthma. Fluticasone propionate administered by Diskhaler (FP Diskhaler, 250 microg twice a day; Glaxo Wellcome, Research Triangle Park, NC) was used as an active control. A randomized, parallel group, double-blind (for MF-DPI dosage), evaluator-blind (for MF-DPI vs FP) trial. Sixty centers in 20 countries. Seven hundred thirty-three patients with moderate persistent asthma on inhaled corticosteroid treatment. Discontinuation of previous inhaled corticosteroid and initiation of one of four study treatments: three doses of MF-DPI (100, 200, and 400 microg twice daily) and one of FP (250 microg twice daily >12 weeks). FEV1 (primary efficacy variable) was evaluated as the mean change from baseline to endpoint (last evaluable visit). All dosage groups showed improvement at endpoint. Only 400 microg twice daily of MF-DPI (+0.19 L) was statistically different from 100 microg twice daily of MF-DPI (+0.07 L; P = 0.02)...Continue Reading
References
Jan 1, 1991·Immunopharmacology and Immunotoxicology·B E BartonM I Siegel
Jan 1, 1990·Respiration; International Review of Thoracic Diseases·G CarpentiereC T Bonanno
Feb 1, 1995·The American Journal of Medicine·N A HananiaS Kesten
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·A K KamadaR F Lemanske
Jan 1, 1996·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S I WassermanD J Kellerman
Aug 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M DrouinB N Lutsky
Oct 1, 1996·The Journal of Allergy and Clinical Immunology·D GraftB Mesarina-Wicki
Apr 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D S PearlmanA Schaberg
May 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I C CrockerR G Townley
Jan 1, 1997·Allergy·S Pedersen, P O'Byrne
Oct 24, 1997·The Journal of Allergy and Clinical Immunology·S P UmlandM M Billah
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·A M WilsonB J Lipworth
Apr 1, 1998·American Journal of Respiratory and Critical Care Medicine·P J BarnesW W Busse
May 1, 1998·The Journal of Allergy and Clinical Immunology·M Johnson
May 1, 1998·The Journal of Allergy and Clinical Immunology·N Barnes
May 9, 1998·The Journal of Allergy and Clinical Immunology·W W BusseR G Townley
Jul 1, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I C CrockerR G Townley
Oct 30, 1999·Respiratory Medicine·D I BernsteinJ E Harrison
May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A S NayakJ E Harrison
Citations
Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Geoff K Frampton, Jonathan Shepherd
Oct 13, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kelli HartRichard Beasley
Mar 9, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kazuyoshi KurashimaYutaka Sugita
Apr 28, 2009·International Journal of Clinical Practice·J Bousquet
Oct 29, 2004·Respiratory Research·Hannu KankaanrantaPeter J Barnes
Aug 3, 2004·Respiratory Research·Anagnostis Valotis, Petra Högger
Nov 19, 2008·Respiratory Research·Peter M A CalverleyHeribert Staudinger
Jan 7, 2010·BMC Pulmonary Medicine·David PriceHeribert Staudinger
Jun 23, 2006·Drugs·Paul L McCormack, Greg L Plosker
Jul 3, 2010·Paediatric Drugs·Henry Milgrom
Apr 7, 2004·Journal of Pharmaceutical Sciences·Anagnostis ValotisPetra Högger
Apr 12, 2002·Chest·Franklin G Miller, Andrew F Shorr
May 31, 2011·The Journal of Allergy and Clinical Immunology·H William Kelly
Aug 23, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·David P SkonerHeribert Staudinger
Oct 10, 2007·Current Medical Research and Opinion·Jill P Karpel, Harold Nelson
Nov 20, 2009·Current Medical Research and Opinion·Yuji Tohda, Terumasa Miyamoto
Nov 19, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Dennis M Williams
Mar 21, 2015·PloS One·Taro KunitomiMayumi Mochizuki
Feb 11, 2016·Journal of Clinical Pharmacology·Taro KunitomiMayumi Mochizuki
Mar 6, 2009·The Annals of Pharmacotherapy·H William Kelly
Jul 2, 2011·Current Opinion in Allergy and Clinical Immunology·Stuart W Stoloff, H W Kelly
Oct 25, 2007·Expert Opinion on Pharmacotherapy·Anthony D'Urzo
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C RoumestanM Mathieu
Oct 31, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jill KarpelRichard F Lockey
Mar 17, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anwar K Abdullah, Salman Khan
Jul 22, 2009·Expert Opinion on Pharmacotherapy·Robert L CowieRichard Leigh
Apr 17, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ulf HarnestGordon Sussman
Dec 16, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Eli O Meltzer, Sally Wenzel
Jan 13, 2009·Pediatric Clinics of North America·Paul D Robinson, Peter Van Asperen