Abstract
We compared gastrointestinal toxicity of single vs. fractionated total body irradiation (TBI) administered at dose rates ranging from 0.021 to 0.75 Gy/min in a canine model of marrow transplantation. Dogs were given otherwise marrow-lethal single or fractionated TBI from dual 60Co sources at total doses ranging from 8-18 Gy and delivered at dose rates of 0.021, 0.05, 0.10, 0.20, 0.40, and 0.75 Gy/min, respectively. They were protected from marrow death by infusion of previously stored autologous marrow cells and they were given intensive supportive care posttransplant. The study endpoint was 10-day mortality from gastrointestinal toxicity. Logistic regression analyses were used to jointly evaluate the effects of dose rate, total dose, and delivery regimen on toxicity. With increasing dose rates, mortality increased for either mode of delivery of TBI. With dose rates through 0.10 Gy/min, mortality among dogs given single vs. fractionated TBI appeared comparable. Beginning at 0.20 Gy/min, fractionation appeared protective for the gastrointestinal tract. Results in dogs given TBI at 0.40 and 0.75 Gy/min, respectively, were comparable, and dose fractionation permitted the administration of considerably higher total doses of TBI tha...Continue Reading
References
Mar 1, 1979·International Journal of Radiation Oncology, Biology, Physics·S BellettiL Magno
Oct 1, 1975·International Journal of Radiation Oncology, Biology, Physics·H R WithersD H Hussey
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H J DeegE D Thomas
Jun 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·U Quast
Jan 1, 1986·International Journal of Radiation Oncology, Biology, Physics·T J FitzGeraldJ S Greenberger
Apr 1, 1969·Transplantation·N GengozianE M Allen
Apr 1, 1983·International Journal of Radiation Oncology, Biology, Physics·G P GlasgowW B Mill
Aug 1, 1981·International Journal of Radiation Oncology, Biology, Physics·B ShankR J O'Reilly
May 1, 1982·International Journal of Radiation Oncology, Biology, Physics·E D ThomasR Storb
Feb 1, 1980·International Journal of Radiation Oncology, Biology, Physics·W C LamE D Thomas
May 20, 1993·International Journal of Radiation Oncology, Biology, Physics·R StorbM Pepe
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·M C BenyunesR Witherspoon
Dec 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B Shank
May 1, 1956·The Journal of Experimental Medicine·T T PUCK, P I MARCUS
Oct 1, 1957·The Journal of Experimental Medicine·T T PUCKS J CIECIURA
Citations
May 27, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maura H ParkerRainer Storb
Aug 18, 2005·Blood·Lauri BurroughsRainer Storb
Apr 6, 2013·Medical Physics·Yuichi AkinoIndra J Das
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yunchuan DingRainer Storb
Nov 19, 2004·Springer Seminars in Immunopathology·Frédéric Baron, Rainer Storb
Dec 19, 2017·International Journal of Radiation Biology·Ayman Khalil, Hasan Omran
Mar 23, 2017·Physics in Medicine and Biology·So-Yeon ParkJong Min Park
May 31, 2019·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Tracy L GiegerSteven E Suter
Dec 12, 2019·Frontiers in Oncology·Michael W NolanMary-Keara Boss