PMID: 8947537Nov 1, 1996Paper

Dose-rate effects on the survival of irradiated hypersensitive and normal human fibroblasts

International Journal of Radiation Biology
C BadieE P Malaise

Abstract

The linear-quadratic model describes cell killing by radiation as due to two processes defined by the linear (alpha) component and by the quadratic (beta) component. As alpha and beta are interdependent, it is difficult to evaluate accurately the alpha component (which characterizes the intrinsic radiosensitivity). It has been suggested that irradiation at low dose-rate (around 1 cGy/min) allows the disappearance of the beta component and thus gives a direct measure of alpha. The present results verify this hypothesis with plateau phase cells. The survival of five human fibroblast cell lines in exponentially growing and density-inhibited, confluent cultures maintained at 37 degrees C following exposure to 60Co gamma-rays at dose-rates of 0.33-100 cGy/min followed by delayed plating (only for plateau phase cells) was monitored. Three of these cell lines are considered to be 'normal' and two are derived from hypersensitive individuals. The mean inactivation doses (D) of the five cell lines for acute doses with immediate plating were 173, 163, 136, 107 and 67 cGy. (D) increased with delayed plating recovery for 4 of the 5 cell lines and the survival of the 5 cell lines increased after low dose-rate exposure (1 cGy/min) without alt...Continue Reading

References

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Citations

Aug 6, 1998·The British Journal of Radiology·R G Dale, B Jones
Jun 4, 2020·Radiation and Environmental Biophysics·Dante OlofssonAndrzej Wojcik

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