Dose reduction and discontinuation of standard-dose regorafenib associated with adverse drug events in cancer patients: a systematic review and meta-analysis

Therapeutic Advances in Medical Oncology
Alessandro RizzoMaria A Pantaleo

Abstract

Regorafenib (REG) is an oral multikinase inhibitor used in colorectal cancer, gastrointestinal stromal tumour and hepatocellular carcinoma. Several adverse events (AEs) are commonly reported during REG administration, and strategies for managing AEs in everyday clinical practice include supportive care, dose modifications and, when necessary, treatment withdrawal. We performed a systematic review and meta-analysis to assess the schedule treatment modifications of REG associated with AEs across randomized controlled clinical trials (RCTs). Eligible studies included RCTs assessing standard dose REG versus placebo. Outcomes of interest included: AE-related permanent discontinuation, dose interruptions and dose reductions. We retrieved all the relevant RCTs through PubMed/Med, Cochrane library and EMBASE: 7 eligible studies involving a total of 2099 patients (Regorafenib: 1362; placebo: 737) were included in our analysis. The use of REG was associated with higher incidence and risk of all outcomes of interest when compared with placebo. The incidences of permanent discontinuation, dose interruptions and dose reductions in patients receiving REG were 9.7%, 57.2% and 47%, respectively, versus 3.3%, 16.7% and 7.7% of placebo group; co...Continue Reading

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Citations

Jan 10, 2021·International Journal of Molecular Sciences·Christos VallilasMichalis V Karamouzis
Feb 8, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo, Giovanni Brandi
Apr 3, 2021·Cancer Treatment and Research Communications·Alessandro RizzoGiovanni Brandi
Apr 3, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo
Apr 7, 2021·Immunotherapy·Alessandro RizzoGiovanni Brandi
Jun 26, 2021·Expert Opinion on Investigational Drugs·Alessandro RizzoGiovanni Brandi
Jul 16, 2021·Therapeutic Advances in Medical Oncology·Margherita NanniniMaria Abbondanza Pantaleo

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