Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome

Journal of Diabetes
Sarine Sebastian KarotGopalan Kutty Nampurath

Abstract

The replacement of the thiazolidinedione moiety with a thiazolidinone may yield antidiabetic compounds with similar pleiotropic effects. Hence, the aim of the present study was to explore the dose-related antihyperglycemic and hypolipidemic effects of two synthesized novel thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS). Metabolic syndrome was induced in Wistar rats by neonatal administration of monosodium glutamate (i.p.) on 4 consecutive days followed by high-sucrose diet feeding for 6 months. The effects of NAT1 (33 and 66 mg/kg) and molar equivalent doses of PAT1 (40 and 80 mg/kg) on relevant biochemical parameters were evaluated. Because MetS is a state of chronic low-grade inflammation, we also evaluated the effects of these compounds on proinflammatory markers, namely interleukin (IL)-6, tumor necrosis factor (TNF)-α, reactive oxygen species (ROS), and nitric oxide (NO). Both NAT1 and PAT1 attenuated hyperglycemia, hypertriglyceridemia, hypoalphalipoproteinemia, and glucose intolerance. PAT1 exhibited superior antihyperglycemic and an...Continue Reading

References

Oct 17, 1968·European Journal of Biochemistry·W G Niehaus, B Samuelsson
Jan 1, 1994·Methods in Enzymology·L MarcocciM Gardès-Albert
May 9, 1998·Journal of Applied Physiology·R J BarnardJ J Berger
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M DolnikoffE Herrera
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Martha M MonickGary W Hunninghake
Sep 27, 2002·Experimental Biology and Medicine·Jérôme BusserollesYves Rayssiguier
Feb 8, 2003·Science·Jeffrey M Friedman
Dec 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yeda S DinizEthel L B Novelli
May 26, 2004·The Journal of Nutritional Biochemistry·Alfonso Alexander AguileraRosa M Oliart Ros
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G MorenoE Spinedi
Dec 7, 2007·Chemico-biological Interactions·Gopalan Kutty NampurathMallikarjuna Rao Chamallamudi
Feb 10, 2009·Current Pharmaceutical Design·Rigas G KalaitzidisGeorge L Bakris
May 1, 2009·Nature Reviews. Drug Discovery·Cyrus DeSouza, Vivian Fonseca
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Mar 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian-Mei LiQing-Hua Hu
Jun 3, 2010·The Journal of Biological Chemistry·Alex Inberg, Michal Linial
Mar 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L A Velloso, M W Schwartz
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Apr 24, 2012·Journal of Nutrition and Metabolism·Faloia EmanuelaBoscaro Marco
Jan 15, 2014·Chemico-biological Interactions·Jayesh MudgalGopalan K Nampurath

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