Dose-related effect of alcohol on mismatch negativity and reaction time performance

Alcohol
I P JääskeläinenR Näätänen

Abstract

In a recent study, the mismatch negativity (MMN) component of auditory event-related potential, elicited by occasional frequency changes in a repetitive tone, was strongly attenuated by a low dosage of alcohol. We investigated the phenomenon in nine subjects with two different dosages of ethanol (0.35 and 0.55 g/kg), and with two magnitudes of frequency changes (5% and 10%), in a single-blind, placebo-controlled paradigm. Ethanol had no observable effect on the N1 and P2 deflections, nor on the reaction time to frequency changes measured in a separate session. However, the MMN was attenuated after administration of the larger dosage of alcohol, suggesting impaired preconscious processing of stimulus features outside the scope of attention. The results support the view according to which the automatic functions of human information processing are more sensitive than the controlled functions to the detrimental effects of alcohol. The fact that the MMN suppression was stronger when stimulus deviation was smaller indicates that at relatively low blood alcohol concentrations the detection of small deviations is especially hampered.

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Citations

Dec 3, 2013·Psychopharmacology·Catherine Berthelon, Guy Gineyt
Mar 8, 1996·Biological Psychology·I P JääskeläinenR Näätänen
Mar 1, 1996·Alcohol·I P JääskeläinenR Näätänen
May 24, 2005·Accident; Analysis and Prevention·Emily L R Harrison, Mark T Fillmore
Feb 26, 1998·Alcohol·I P JääskeläinenP Sillanaukee
Dec 25, 2002·Experimental and Clinical Psychopharmacology·Mark T Fillmore, Mark Van Selst
Dec 2, 2004·Experimental and Clinical Psychopharmacology·Ben D Abroms, Mark T Fillmore
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Feb 14, 2021·Biological Psychiatry·Catharine E FairbairnKara D Federmeier

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