PMID: 1201162Aug 1, 1975Paper

Dose relationships of phase II, tachyphylaxis and train-of-four fade in suxamethonium-induced dual neuromuscular block in man

British Journal of Anaesthesia
C Lee

Abstract

In man under halothane-nitrous oxide-oxygen anaesthesia, suxamethonium-induced neuromuscular block can be divided into two phases using the train-of-four ratio: the first phase of minimal train-of-four fade and the second phase of marked train-of-four fade. The second phase is characterized by a low train-of-four ratio, 0.3 or less, and resembles tubocurarine-block) in many details. It corresponds to Phase II (dual block in the literature. Contrary to the prevailing belief, Phase II block has a rather abrupt onset. In this study of seven patients, Phase I covered up to a total of 1--3 mg/kg of suxamethonium, while 3--5 mg/kg established Phase II block, with a transitional zone of only 2 mg/kg. Establishment of Phase II also coincided with onset of unequivocal tachyphylaxis. The possibility of a causal relationship between tachyphylaxis and Phase II block is suggested.

Citations

Jan 1, 1987·International Journal of Clinical Monitoring and Computing·H H Ali
Sep 1, 1983·Canadian Anaesthetists' Society Journal·D R Bevan, F Donati
Jan 1, 1982·Canadian Anaesthetists' Society Journal·F Donati, D R Bevan
Sep 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E Hudes, K C Lee
Nov 1, 1983·Canadian Anaesthetists' Society Journal·M E FutterD R Bevan
Sep 1, 1993·Anaesthesia·A BarakaV Yazbeck
Sep 1, 1987·Anaesthesia·A P Wainwright, P M Brodrick
Dec 1, 1980·Acta Anaesthesiologica Scandinavica·T Tammisto, M Salmenperä
Sep 19, 1988·The Medical Journal of Australia·T A Torda
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen
May 1, 1981·The Veterinary Clinics of North America. Large Animal Practice·L V Klein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Anaesthesia
W W MUSHIN, W W MAPLESON
ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
M KawaidaN Kohno
Anesthesiology Clinics
Peng Xiao, Xiangwei Shannon Zhang
© 2022 Meta ULC. All rights reserved