Dose-response and efficacy of spinal manipulation for care of cervicogenic headache: a dual-center randomized controlled trial

The Spine Journal : Official Journal of the North American Spine Society
Mitchell HaasMoni Blazej Neradilek

Abstract

The optimal number of visits for the care of cervicogenic headache (CGH) with spinal manipulative therapy (SMT) is unknown. The present study aimed to identify the dose-response relationship between visits for SMT and chronic CGH outcomes and to evaluate the efficacy of SMT by comparison with a light-massage control. This is a two-site, open-label randomized controlled trial. Participants were 256 adults with chronic CGH. The primary outcome was days with CGH in the previous 4 weeks evaluated at the 12- and 24-week primary end points. Secondary outcomes included CGH days at remaining end points, pain intensity, disability, perceived improvement, medication use, and patient satisfaction. Participants were randomized to four dose levels of chiropractic SMT: 0, 6, 12, or 18 sessions. They were treated three times per week for 6 weeks and received a focused light-massage control at sessions when SMT was not assigned. Linear dose effects and comparisons with the no-manipulation control group were evaluated at 6, 12, 24, 39, and 52 weeks. The present study was funded by the National Center for Complementary and Integrative Health (R01AT006330) and is registered at ClinicalTrials.gov (NCT01530321). The authors declare no conflicts of ...Continue Reading

Associated Clinical Trials

Feb 9, 2012·Mitchell Haas

Citations

Mar 20, 2019·Current Neurology and Neuroscience Reports·Rebecca Barmherzig, William Kingston
Jul 6, 2020·European Journal of Pain : EJP·Matthew FernandezAndré Bussières
Sep 29, 2020·NeuroRehabilitation·Brigid Dwyer, Nathan Zasler
May 30, 2019·Chiropractic & Manual Therapies·Mégane PasquierMartin Descarreaux
Jul 6, 2019·Journal of Manipulative and Physiological Therapeutics·Steven R PassmoreBrian J MacNeil
Oct 15, 2020·Cephalalgia : an International Journal of Headache·Pamela M RistPeter M Wayne
Sep 29, 2020·Physical Medicine and Rehabilitation Clinics of North America·Nathan HinkeldeyJamal Khan

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