Jan 20, 2000

Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats

Psychopharmacology
M L SiposG Galbicka

Abstract

In order to facilitate direct comparisons of anticholinergic drug effects on activity, nine drugs were tested in one laboratory using a standardized procedure. The present study compared the effects of aprophen hydrochloride, atropine sulfate, azaprophen hydrochloride, benactyzine hydrochloride, biperiden hydrochloride, diazepam, procyclidine hydrochloride, scopolamine hydrobromide, and trihexyphenidyl hydrochloride on activity levels in rats. Both fine motor activity (reflecting smaller movements) and ambulatory activity (reflecting larger movements) were recorded for 23 h following drug administration in food-restricted rats. All drugs were administered during the light period of the photocycle. Atropine, azaprophen, biperiden, scopolamine, and trihexyphenidyl increased both ambulations and fine motor activity significantly during the first hour post-injection, but the increased activity levels returned to vehicle control levels within 2-6 h post-injection. Benactyzine and procyclidine only increased fine motor activity significantly above vehicle control levels and activity levels returned to vehicle control levels within 2-3 h. Finally, aprophen and diazepam generally did not increase measures of activity significantly abov...Continue Reading

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Mentioned in this Paper

Molecular Motor Activity
Anticholinergic mydriatics and cycloplegics
Azaprophen
Aprofen
Anticholinergics inhalants for obstructive airway diseases
Scopolamine Hydrobromide
Biperiden Hydrochloride
Atropine
Atropinum, atropine
Scopolamine

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