PMID: 7538433Feb 1, 1995Paper

Dose response effects of hypertonic saline and dextran on cardiovascular responses and plasma volume expansion in sheep

Shock
M A DubickG C Kramer

Abstract

Despite the established efficacy of 7.5% NaCl/6% dextran-70 in the treatment of hypovolemia, the optimal formulation of a hyperosmotic/hyperoncotic small volume resuscitation solution has yet to be defined. The present study investigates the cardiovascular effects of hypertonic saline ranging from 3.75%-25% NaCl (HS) and dextran-70 (D-70) ranging from 3 to 24%. HS and D-70 were studied alone or in specific combinations at a dose of 4 mL/kg, in euvolemic sheep. Blood samples were collected before, during and up to 60 min after infusion of the test solutions. Dose-dependent effects of HS were immediate increases in cardiac output (CO) of 30-85%, falling to 10-35% over baseline after 60 min. HS concentrations over 3.75% significantly reduced systemic vascular resistance, but HS had no significant effect on mean arterial pressure (MAP). Plasma volume (PV) expansion with HS was an immediate, but transient increase of 12-35%. Infusion of D-70 induced sustained 10-20% increases in CO and 10-30% increases in PV, peaking 10 min post-infusion. D-70 also resulted in small (5-12 mmHg) increases in MAP. Cardiovascular effects of D-70 correlated with a dose-dependent increase in plasma dextran concentrations. All HS solutions significantly i...Continue Reading

Citations

Feb 18, 2010·Shock·Heena P Santry, Hasan B Alam
Apr 11, 2008·The Journal of Trauma·George C KramerCharles E Mitchell
Sep 16, 2010·Anesthesia and Analgesia·João M P BarrosJosé R C Braz
Mar 10, 2001·The Journal of Trauma·J A DoyleD B Hoyt
Dec 18, 2015·Surgical Neurology International·Myles Dustin BooneEkkehard M Kasper
Jan 27, 2004·The Veterinary Clinics of North America. Equine Practice·Janyce L Seahorn, Thomas L Seahorn
Oct 21, 1998·Perfusion·S TølløfsrudG C Kramer
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Stefan SchwarzStefan Schwab

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