PMID: 9160568Jan 1, 1994Paper

Dose-response effects of intravenous caffeine in normal volunteers

Anxiety
P V Nickell, T W Uhde

Abstract

The administration of caffeine has been developed as a chemical model for the study of anxiety. However, previous researchers investigating caffeine-induced anxiety states in humans have administered oral caffeine. In this dose-response study, we investigated the effects of blindly administered intravenous caffeine (3, 5, and 7 mg/kg) versus placebo in normal control subjects. We report the first series of subjects experiencing olfactory hallucinations (10 of 10 subjects, 24 of 30 infusions) immediately following intravenous caffeine infusion. In addition, consistent with our previous work with oral caffeine, we found dose-related increases in ratings of anxiety and blood levels of cortisol and lactate. One subject experienced a DSM-III-R panic attack. Further questioning revealed that his mother suffers panic attacks. Our findings of olfactory hallucinations are discussed within the context of localized limbic system dysfunction, noting the phenomenologic and possible neuroanatomic overlap between panic disorder and complex partial seizures.

References

Oct 15, 1992·The New England Journal of Medicine·K SilvermanR R Griffiths
Mar 1, 1992·The American Journal of Psychiatry·C H Kellner, D L Bachman
Jun 1, 1989·The American Journal of Psychiatry·L A PappJ M Gorman
Sep 1, 1989·The American Journal of Psychiatry·T A Mellman, T W Uhde
Feb 1, 1989·Archives of General Psychiatry·T A Mellman, T W Uhde
Mar 1, 1985·Archives of General Psychiatry·D S CharneyP I Jatlow
Sep 1, 1988·The American Journal of Psychiatry·T W UhdeR M Post
Jan 1, 1973·The American Journal of Psychiatry·S H Snyder
Nov 1, 1971·Psychosomatics·W W Zung
Jan 1, 1967·Psychotherapy and Psychosomatics·S Lorand
Sep 1, 1966·Archives of General Psychiatry·M B Bowers, D X Freedman
Jan 1, 1984·Psychopathology·M RaineyR Berchou
Jan 1, 1984·Journal of Psychiatric Research·S H Snyder, P Sklar
Jul 17, 1981·European Journal of Pharmacology·M E LewisP J Marangos
May 1, 1983·Annals of Internal Medicine·P W Curatolo, D Robertson
Nov 1, 1984·Archives of General Psychiatry·J P BoulengerR M Post
Aug 1, 1984·Archives of General Psychiatry·M R LiebowitzS O Davies
Dec 1, 1993·The American Journal of Psychiatry·H W KoenigsbergJ Fine
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Jul 29, 2009·Current Psychiatry Reports·Thomas W UhdeAndrei Vedeniapin
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Sep 29, 1999·Progress in Neurobiology·P SvenningssonB B Fredholm
Oct 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
Apr 5, 2014·TheScientificWorldJournal·Sadaqat Ullah KhanNasir Shafiq
Jul 29, 2010·Expert Review of Neurotherapeutics·C JacobJuergen Deckert
Oct 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vasilios G MasdrakisPanagiotis Oulis
Nov 14, 2007·Metabolism: Clinical and Experimental·Todd MacKenzieJohn A Baron
Aug 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vasilios G MasdrakisConstantin R Soldatos
Apr 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Diogo R LaraMiriam G Brunstein
Apr 8, 2015·Journal of Affective Disorders·Bernadette M CorteseThomas W Uhde
Aug 25, 2009·Psychiatry Research·Antonio E NardiWalter A Zin
Jul 11, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Barbara M ThomsonBeverley Horn
Aug 10, 2016·Frontiers in Psychiatry·Sahib S Khalsa, Rachel C Lapidus
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven P HamiltonJames A Knowles
Sep 27, 2005·Depression and Anxiety·Michael BonnetVikram K Yeragani
Sep 28, 2018·CNS Spectrums·David C HoughtonBernadette M Cortese
Sep 3, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vidya PereraAndrew J McLachlan
Aug 26, 2011·Anxiety, Stress, and Coping·Johanna S KaplanPaul J Carlson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

Archives of General Psychiatry
R R CroweL J Ward
The Journal of Neuropsychiatry and Clinical Neurosciences
Toshiya Murai, Shunsuke Takagi
© 2021 Meta ULC. All rights reserved