PMID: 1208764Nov 21, 1975Paper

Dose-response effects of scopolamine on activity in an open field

Psychopharmacologia
W J Stewart, S Blain

Abstract

The frequency of the responses, i.e., squares entered (ambulation), rearing and grooming, were recorded over 30 min for saline, and 0.25, 1.0, 2.0 and 4.0 mg/kg scopolamine treated groups. Scopolamine produced an inverted U dose-response curve for ambulation, an increase in rearing but no effect on grooming. All three responses decreased over time; scopolamine did not attenuate this rate of habituation. There did appear a dose-related time effect. It was concluded that scopolamine may have different effects on various responses recorded simultaneously over a range of doses. The results when compared to other experiments emphasized the importance of environmental factors in determining drug effects on behaviour.

References

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·R N HughesW J Stewart
Jan 1, 1972·Psychopharmacologia·W G DrewA Wikler
Jan 1, 1970·Psychopharmacologia·S N Pradhan, S N Dutta
Feb 1, 1971·Journal of Comparative and Physiological Psychology·K A Khavari
Jan 1, 1968·Psychopharmacologia·S N Pradhan, T Roth
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Apr 1, 1959·Journal of the Experimental Analysis of Behavior·J J BOREN, A P NAVARRO
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Citations

Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·P R SanbergL J Harkabus
Mar 6, 2004·Neurotoxicology and Teratology·Tracey E SamsamPhilip J Bushnell
Dec 12, 1997·The International Journal of Neuroscience·M PopovićN Rosić
Sep 1, 1996·The International Journal of Neuroscience·M PopovićL Rakić
Jun 1, 1977·Psychological Reports·W Stewart, N Stewart
Oct 18, 2016·Journal of Pharmacological and Toxicological Methods·David V GauvinTheodore J Baird
Oct 1, 1976·Psychological Reports·W Stewart, P Woods

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