PMID: 9416722Jan 7, 1998Paper

Dose-response of rocuronium bromide in children anesthetized with propofol: a comparison with succinylcholine

Anesthesiology
R L WoolfS M Choo

Abstract

The aim of this study was to determine the potency of rocuronium during propofol/fentanyl/N2O anesthesia in children and to compare the time course of action of rocuronium at doses of two and three times the ED95 with that of succinylcholine. Rocuronium (120, 160, 200, or 240 microg/kg) was administered to 48 children aged 2-10 yr. Neuromuscular block was assessed by monitoring the electromyographic response of the adductor digiti minimi to supramaximal stimulation of the ulnar nerve at 2 Hz for 2 s every 10 s. Potency was determined by log-probit transformation and least-squares linear regression analysis of dose and response. In a second group of 30 children, the onset and recovery profile of rocuronium at doses of two and three times the ED95 was compared with that of succinylcholine (2 mg/kg). Values for ED50 and ED95 were 210 +/- 24 and 404 +/- 135 microg/kg, respectively. The time to 90% neuromuscular block after 1.2 mg/kg rocuronium (three times the ED95), 33 +/- 5 s (mean +/- SD), did not differ significantly from that after succinylcholine, at 30 +/- 7 s; however, both were significantly less than that after 0.8 mg/kg rocuronium, 46 +/- 8 s (P < 0.05). The time to 25% recovery from 1.2 microg/kg rocuronium, 41 +/- 13 m...Continue Reading

References

Mar 1, 1990·Anesthesia and Analgesia·J F PittetE Tassonyi
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Citations

Sep 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·U M Klemola, A Hiller
Jan 4, 2001·Pediatric Emergency Care·K A Doobinin, T A Nakagawa
Jan 23, 2009·European Journal of Anaesthesiology·Harald IhmsenTino Muenster
Oct 22, 2008·Journal of Clinical Anesthesia·WangNing ShangGuanFang Gao
Jan 10, 2012·Anesthesiology·Gilles A OrliaguetVincent Couloigner
Jan 12, 2000·Pediatric Clinics of North America·J D McAllister, K A Gnauck
Jul 24, 2004·Anesthesia and Analgesia·TaeHyung HanJ A Jeevendra Martyn
Oct 30, 2015·The Cochrane Database of Systematic Reviews·Diem T T TranJeffrey J Perry
Feb 1, 2020·Minerva anestesiologica·Simonetta TesoroEdoardo De Robertis
Nov 20, 1998·Seminars in Perinatology·D J Mellor, J Lerman
May 16, 2000·Anesthesia and Analgesia·D Ryan Cook

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