Dose-response of ropivacaine administered caudally to children undergoing surgical procedures under sedation with midazolam

Clinical and Experimental Pharmacology & Physiology
F Tonatiu Aguirre-GarayAlejandro A Nava-Ocampo

Abstract

1. In a double-blind randomized controlled design, 50 children were allocated to receive bupivacaine 0.25% or ropivacaine 0.25%, 0.32%, 0.40% or 0.50% by caudal block. 2. Caudal block was performed after induction of anaesthesia with 2-5% sevoflurane, atropine 10 microg/kg and midazolam 100-300 microg/kg. During the surgical procedure, patients were maintained under spontaneous ventilation and no intravenous or inhalatory anaesthetic agent was administered. For transoperative sedation, midazolam 100-300 microg/kg was administered every 0.5-1.0 h. Transoperative cardiovascular response, postoperative analgesia and local and systemic complications were evaluated. 3. Groups were similar (P > 0.05) in sex, age, weight and in the time elapsed from caudal block to the beginning of the surgical procedure. The surgical time was significantly lower in the ropivacaine 0.25% group. The duration of analgesia was 24 h with ropivacaine 0.25% and approximately 10 h in the other four groups (P < 0.001). Linear regression analysis revealed a significant relationship between the postoperative analgesic period produced by ropivacaine and the surgical time (r = -0.48, two-sided P = 0.002). Systolic and diastolic blood pressures remained in the phy...Continue Reading

References

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Nov 7, 1999·Anesthesiology·S KhalilA Chuang
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Alejandro A Nava-Ocampo, Angélica M Bello-Ramírez

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Citations

Sep 17, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Elisabeth F A DobereinerDavid R Lardner
Mar 15, 2006·Current Opinion in Anaesthesiology·Pasquale De NegriAnna Claudia Del Piano
Feb 20, 2009·Anesthesia and Analgesia·Pablo IngelmoAntonio Gullo

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