Dose response of the AIA rabbit stifle joint to boron neutron capture synovectomy

Nuclear Medicine and Biology
Sonya ShortkroffJ C Yanch

Abstract

This study assessed the treatment with boron neutron capture synovectomy of synovitis in the antigen-induced arthritis (AIA) model. A boron compound, potassium dodecahydrododeca-borate (K(2)B(12)H(12)), was injected into stifle joints of 24 AIA and 12 normal rabbits and activated by neutron bombardment of the joint to achieve doses from 800 to 81,000 RBE-cGy. Synovial ablation in the AIA joint was accomplished at doses of 6,000 to 7,000 RBE-cGy with no adverse effects to skin or extracapsular tissues.

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Citations

Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Dimitri Dimitroyannis
Jul 30, 2009·International Journal of Radiation Biology·Peter L E M van LentWim B van den Berg
Apr 18, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S NievaartR Moss
Oct 16, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Khalid AbdallaB Elshahat

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