Dose response of thyrotropin-releasing hormone on pulmonary maturation in corticosteroid-treated preterm rabbits

American Journal of Obstetrics and Gynecology
B L TaborS B Oetomo

Abstract

The dose-response effect of thyrotropin-releasing hormone in enhancing pulmonary maturation was investigated with six dosing regimens. Pregnant does received thyrotropin-releasing hormone (5, 10, or 50 micrograms/kg every 12 hours for four doses or one dose of 20 micrograms/kg) in conjunction with betamethasone beginning on day 25 of gestation, with betamethasone alone or saline solution used as comparison treatment groups. Half of the newborn rabbits received supplemental surfactant therapy after delivery on day 27, and all were ventilated on a ventilator plethysmography system for 30 minutes. There were no differences among the four thyrotropin-releasing hormone doses in surfactant pool sizes, compliances, or proteins leak into or out of the air spaces. The groups that received multiple doses of thyrotropin-releasing hormone had significantly higher perinatal loss rates than the single-dose group. The lungs of the group treated with thyrotropin-releasing hormone plus steroid and the rabbits treated only with steroid were more compliant than the controls without surfactant therapy, and showed significant improvements in protein leak. The addition of thyrotropin-releasing hormone to betamethasone improved several of the protein...Continue Reading

References

Jan 1, 1986·Biology of the Neonate·M IkegamiD Berry
Jul 1, 1982·Pediatric Research·T HednerD Lundberg

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Citations

Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·J G Thorpe-BeestonA M McGregor
Sep 1, 1992·American Journal of Obstetrics and Gynecology·B L TaborA H Jobe
Dec 1, 1991·Annals of Medicine·M HallmanK Bry

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