Dose-response relationship and effective time to satisfactory intubation conditions after rocuronium in children

Anaesthesia
J M HopkinsonR D Baker

Abstract

We assessed the neuromuscular blocking effects of, and intubation conditions following, rocuronium in 81 children aged 2-12 years. The study was conducted in three parts. Parts 1 and 2 were undertaken during anaesthesia with thiopentone, alfentanil and nitrous oxide. Neuromuscular blockade was evaluated by recording the force of contraction of the adductor pollicis in response to train-of-four stimulation at 2 Hz repeated every 10s. In Part 1 the potency of rocuronium was determined in 15 children using a single dose-response technique; in Part 2 onset and recovery times were determined in six children following rocuronium 0.6 mg.kg-1. In Part 3 of the study, intubation conditions were assessed in five groups of 12 children whose tracheas were intubated 30, 40, 50, 60 and 70s after rocuronium 0.6 mg.kg-1 during anaesthesia with thiopentone. The times to satisfactory intubation conditions in 50% and 90% of children were determined by probit analysis. The effective doses of rocuronium to produce 50% and 95% twitch depression were 151 micrograms.kg-1 (95% confidence intervals: 129-173 micrograms.kg-1) and 331 micrograms.kg-1 (95% confidence intervals: 249-543 micrograms.kg-1), respectively. The mean times (SD) to 90% and 100% depr...Continue Reading

Citations

Jul 11, 1998·Anaesthesia·G Meakin
Nov 7, 2001·Paediatric Anaesthesia·G H Meakin
Jan 4, 2001·Pediatric Emergency Care·K A Doobinin, T A Nakagawa
May 5, 2007·Current Opinion in Anaesthesiology·George H Meakin
May 14, 2005·Current Opinion in Pediatrics·Audrey Zelicof-PaulPeter Dayan
May 16, 2000·Anesthesia and Analgesia·Barbara W Brandom

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