Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus

Chest
T R HsiueH Y Chang

Abstract

To determine the dose-response aspect of pulmonary function impairment in patients with consumption of Sauropus androgynus for weight reduction. A questionnaire and pulmonary function tests were performed in 194 patients with a history of consumption of S androgynus with or without chest symptoms. Patients with obstructive ventilatory defect received follow-up spirometry 22 to 24 months after beginning consumption of the vegetable. Data from 178 patients were analyzed. Patients generally consumed 150 g of S androgynus daily as raw juice (60.7%), sauteed (16.9%), mixed preparation (20.8%), or boiled (1.7%) for various periods of time. We divided patients into five groups according to the total dose consumed (group A, 0 to 1,799 g; group B, 1,800 to 3,599 g; group C, 3,600 to 5,399 g; group D, 5,400 to 7,199 g; and group E, > or =7,200 g). The frequency of obstructive ventilatory defect was higher in the high-dose group than in the low-dose group (A, 4/43=9.3%; B, 13/64=20.3%; C, 14/32=43.8%; D, 5/12=41.7%; and E, 13/27=48.1%; p < 0.01). In total, 49 patients (27.5%) had moderate to severe obstructive ventilatory defects without bronchodilator response. The FEV1 and FEV1 percent predicted in these 49 patients were 0.96+/-0.38 L (...Continue Reading

References

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Citations

Apr 13, 2005·Respiration; International Review of Thoracic Diseases·Kenichi OonakaharaYoshinori Hasegawa
Aug 1, 2007·Expert Review of Respiratory Medicine·Gary R Epler
Oct 15, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Ying OuTzuen-Ren Hsiue
Jul 31, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shih-Fing YuYen-Hui Chen
May 6, 2010·Archives of Pathology & Laboratory Medicine·Timothy Craig Allen

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