PMID: 7030120Sep 1, 1981Paper

Dose-response relationship for disoprofol (ICI 35868; Diprivan). Comparison with methohexitone

Anaesthesia
B Kay, D K Stephenson

Abstract

The duration of sleep following intravenous administration of three doses of disoprofol (1.2 and 3 mg/kg) was compared with that following methohexione 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side-effects were dose-related for both drugs, but the incidence was significantly less following disoprofol than methohexitone 2 mg/kg. The most frequent side-effects were pain on injection, myoclonia and hiccup. Studies of blood concentrations of disoprofol show that the profile is dose-independent and conforms to a two-compartment model with a very short distribution phase (about 2 minutes) and short elimination phase (about 70 minutes). Waking blood levels gave no indication of acute tolerance. Disoprofol would appear to be particularly useful for induction of a short period of sleep using a small dose given quickly, or for maintenance of sleep by continuous infusion.

Citations

Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C H McLeskey
Apr 30, 2003·Journal of Clinical Anesthesia·Luc L HerregodsEric Mortier
Aug 18, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giovanni MoraniCorrado Vassanelli
Apr 1, 1983·Acta Anaesthesiologica Scandinavica·R J FragenJ F Crul
May 1, 1986·Acta Anaesthesiologica Scandinavica·J P FeeJ W Dundee
Sep 1, 1987·Anaesthesia·B Kay

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