Dose-response relationship for mivacurium in patients with phenotypically abnormal plasma cholinesterase activity

Acta Anaesthesiologica Scandinavica
D OstergaardJ Viby-Mogensen

Abstract

During thiopentone-fentanyl-nitrous oxide anaesthesia and using a cumulative design, we studied the dose-response relationship of mivacurium in 8 patients: 7 patients phenotypically homozygous for the atypical plasma cholinesterase gene and 1 patient homozygous for the silent gene. The estimated mean ED50 and ED95 were 15 and 20 micrograms.kg.bw-1 in patients homozygous for the atypical gene, and 13 and 16 micrograms.kg.bw-1 in the patient homozygous for the silent gene, respectively. The results indicate that mivacurium is 4-5 times more potent in patients homozygous for the atypical or the silent gene than in patients with normal plasma cholinesterase activity and phenotype.

References

Jan 1, 1977·Acta Anaesthesiologica Scandinavica·J Viby-Mogensen, H K Hanel
Apr 1, 1989·Anesthesia and Analgesia·D R CookR M Welch
Nov 1, 1974·Anesthesia and Analgesia·J V DonlonJ J Savarese
Feb 1, 1995·British Journal of Anaesthesia·I Sockalingam, D W Green
Feb 1, 1995·British Journal of Anaesthesia·M H Fox, P C Hunt
Feb 1, 1995·Acta Anaesthesiologica Scandinavica·F S JensenJ Viby-Mogensen
Jul 1, 1993·Anesthesia and Analgesia·N G GoudsouzianJ Viby-Mogensen
Apr 1, 1993·Acta Anaesthesiologica Scandinavica·D OstergaardJ Viby-Mogensen
Jan 1, 1993·Anesthesia and Analgesia·R S PetersenE R Ashwood
Jun 1, 1993·Anesthesiology·V R Maddineni, R K Mirakhur

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Citations

Dec 4, 1998·Annales Françaises D'anesthèsie Et De Rèanimation·C LejusR Souron
Feb 26, 2005·Anesthesiology·Stephen N PalmerCharles D Collard
Jan 22, 2003·Drugs & Aging·Tristan M Cope, Jennifer M Hunter
Apr 28, 2007·European Journal of Anaesthesiology·M A CheongG S Lee
Nov 1, 1995·Acta Anaesthesiologica Scandinavica·J Viby-Mogensen

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