Dose-response relationships between occupational exposure to potash, diesel exhaust and nitrogen oxides and lung function: cross-sectional and longitudinal study in two salt mines.

International Archives of Occupational and Environmental Health
Gabriele LotzW Dietmar Schneider

Abstract

Several studies have shown that underground salt miners may have an increased incidence of chest symptoms and sometimes decreased lung function. Miners of two salt mines were investigated to evaluate relationships between the lung function and the workplace exposure. The effect of nitrogen monoxide (NO) and nitrogen dioxide (NO(2)) was investigated in view of the recent debate on European occupational exposure limits. A total of 410/463 miners (mine A/mine B) were examined cross-sectional and 75/64% of the first cohort were examined after a 5-year period. Exposure was measured by personal sampling. Personal lifetime exposure doses of salt dust, diesel exhaust, NO(2) and NO were calculated for all miners. Dose-response relationships were calculated by multiple regression analysis. Each exposure component acted as an indicator for the complex exposure. Exposure response relationships were shown in the cross-sectional and longitudinal investigations in both mines. In the 5-year period, the adjusted (age, smoking, etc.) effect of the exposure indicators resulted in a mean decrease of FEV(1) between -18 ml/year (mine A) and -10 ml/year (mine B). The personal concentrations related to this effect were 12.6/7.1 mg/m(3) inhalable dust,...Continue Reading

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Citations

Jun 15, 2007·International Archives of Occupational and Environmental Health·Dirk DahmannHeinrich Sönksen
Apr 9, 2009·International Archives of Occupational and Environmental Health·Dirk DahmannFrank Gast
Sep 9, 2010·Industrial Health·Todd SchoonoverJulie Plavka
Mar 16, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Souheil HallitPascale Salameh
Feb 21, 2019·Inhalation Toxicology·Wei-Chung SuJinxiang Xi
Aug 21, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xue CaoShuguang Leng

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