Dose-response relationships for polyhalogenated dioxins and dibenzofurans following subchronic treatment in mice. I. CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin

Toxicology and Applied Pharmacology
M J DeVitoL S Birnbaum

Abstract

The dose-response relationships for induction of liver, lung, and skin ethoxyresorufin-O-deethylase (EROD) activity and liver acetanilide-4-hydroxylase (ACOH) activity following subchronic exposure to either 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrabromodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), or octachlorodibenzofuran (OCDF) were determined in female B6C3F1 mice in order to estimate the relative enzyme inducing potency of these chemicals in three different tissues. The relative potencies were calculated based on tissue concentrations as well as administered dose. A dose-dependent induction of EROD activity in liver, lung, and skin and of ACOH activity in liver was found for all seven chemicals. When based on administered dose, the relative potencies for specific congeners did not vary substantially among tissues. The relative potencies for TCDF and 1-PeCDF, congeners which have much shorter half-lives than TCDD, increased for all enzymes when estimated from tissue concentrations. The relative potency of OCDF, which is poorly absorbed, was greater when estimated from t...Continue Reading

Citations

Jul 27, 2000·Food Additives and Contaminants·L S Birnbaum, J Tuomisto
Jun 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lesa L AylwardSteven C Lewis
May 22, 2009·Archives of Environmental Contamination and Toxicology·Jeremy N MooreJohn P Giesy
Feb 11, 2015·Archives of Toxicology·Franco Scinicariello, Christopher Portier
Nov 3, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrea C AragonMary K Walker
Feb 17, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E L GregoraszczukE Ropstad
Aug 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna K KopecTimothy R Zacharewski
May 16, 2013·Environmental Health Perspectives·Karin I van EdeMajorie B M van Duursen
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Linda S Birnbaum
Nov 30, 1998·Environmental Health Perspectives·M Van den BergT Zacharewski
Jan 1, 2005·Environmental Health Perspectives·Nigel J WalkerChristopher J Portier
Aug 27, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laurie C HawsLinda S Birnbaum
Sep 28, 2010·Environmental Toxicology and Chemistry·William StansleyRoger Thomas
Mar 16, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin van den BergRichard E Peterson
Mar 18, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alhaji N'JaiTimothy R Zacharewski
Feb 4, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert A BudinskyThomas B Starr
May 11, 2005·The Journal of Biological Chemistry·Dongxiao ShenHoward G Shertzer
Jan 8, 2021·Biometrical Journal. Biometrische Zeitschrift·Lucy X Kerns
Nov 9, 2020·The Science of the Total Environment·Alwyn R Fernandes, Jerzy Falandysz
Apr 22, 2004·Chemosphere·David J BrownGeorge C Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.