Dose-response relationships in hepatic injury produced by alcohol and carbon tetrachloride

Alcoholism, Clinical and Experimental Research
J L PlummerR A Williams

Abstract

Dose-response relationships were examined for the production of hepatic fibrosis and cirrhosis by combined exposure of male Porton rats to alcohol and carbon tetrachloride. Alcohol was administered orally in Lieber-DeCarli liquid diet at levels of 75, 150, or 300 kcal/liter, giving mean daily intakes of 2.29, 4.61, and 8.16 g/kg/day, respectively. Carbon tetrachloride was administered by inhalation at concentrations of 10, 20, or 40 ppm, 6 hr/night, 5 nights/week. Liver biopsies were taken at intervals up to a maximum treatment period of 20 weeks. All four rats that received the high dose of both agents, and 1 of 4 that received the medium alcohol and high carbon tetrachloride treatments, were cirrhotic by 10 weeks. Two of the 4 rats that received the low alcohol and high carbon tetrachloride dose were cirrhotic at 20 weeks. Cirrhosis was not observed in rats that received the low or medium carbon tetrachloride dose, but some degree of hepatic fibrosis was observed in all treatment groups. Severity of fibrosis was significantly associated with both dose of alcohol and dose of carbon tetrachloride received. It is concluded that, in the alcohol-carbon tetrachloride rat model for chronic liver injury, both alcohol and carbon tetra...Continue Reading

References

Oct 18, 1976·JAMA : the Journal of the American Medical Association·D S FollandD R McMurray
Nov 1, 1991·Journal of Hepatology·P J Scheuer
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P D HallM J Cousins
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharbonneauG L Plaa
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·C S Lieber, L M DeCarli
Jan 1, 1981·Advances in Experimental Medicine and Biology·M W Anders, R N Harris
Jan 1, 1993·Critical Reviews in Toxicology·J L RaucyJ M Lasker

Citations

Feb 2, 2010·BMC Veterinary Research·Andréia S LessaR C S Goldenberg
Aug 1, 1997·Pathology·P L CmielewskiP M Hall
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MackinnonP D Hall
Jul 20, 2018·Alcoholism, Clinical and Experimental Research·Feifei GuoYulia A Nevzorova
Dec 1, 1994·Alcoholism, Clinical and Experimental Research·J L PlummerM J Ahem
Jan 25, 2019·Scientific Reports·Branko StefanovicLela Stefanovic

Related Concepts

Alcohol Consumption
Metazoa
Toxic Effect of Carbon Tetrachloride
Dose-Response Relationship, Drug
Liver
Liver Cirrhosis, Alcoholic
Liver Cirrhosis, Experimental
August Rats
Rats, Laboratory

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