PMID: 6537911Jan 1, 1984Paper

Dose-response relationships of chronic adriamycin toxicity in rabbits

European Journal of Cancer & Clinical Oncology
H J LongR A Burningham

Abstract

Doxorubicin was administered chronically to 55 female New Zealand White rabbits in order to determine a chronic dose-response relationship for doxorubicin-induced cardiomyopathy, skeletal myopathy and nephropathy. Systolic time interval recording as a measure of cardiac function in doxorubicin-induced cardiomyopathy in the rabbit is compared to histologic grading of the cardiomyopathy. Histologic evidence of cardiomyopathy was not seen at cumulative doses less than 100 mg/m2 but incidence and severity of cardiomyopathy increased with increasing doxorubicin dosage. The most severe lesions were seen at cumulative doses in excess of 400 mg/m2. The dose-response of skeletal myopathy paralleled that of cardiomyopathy but the severity of histologic abnormalities and the incidence of skeletal myopathy was less than half that of cardiomyopathy at all dose levels. Nephropathy was a consistent finding at cumulative doses of doxorubicin in excess of 100 mg/m2.

References

Sep 1, 1976·Cancer Treatment Reviews·L Lenaz, J A Page

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Citations

Jan 1, 1995·Urological Research·G Gadeholt-GöthlinJ H Göthlin
May 8, 2007·The Spine Journal : Official Journal of the North American Spine Society·Kern SinghS Tim Yoon
Nov 16, 2004·The Spine Journal : Official Journal of the North American Spine Society·P Justin TortolaniS Tim Yoon
Jan 24, 2003·Human & Experimental Toxicology·Ivona KlimtováMichaela Adamcová
Jan 28, 2003·Muscle & Nerve·Joern P Sieb, Thomas Gillessen
Feb 1, 1995·Journal of Surgical Oncology·G Gadeholt-Göthlin, J H Göthlin

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