Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents

Toxicology
T DoiT Suzuki

Abstract

Our previous study revealed the appropriate conditions for the plaque- forming cell (PFC) assay in rats. Using this assay in the present study, dose-response relationships of cytotoxicity, PFC response and histology in the spleen were evaluated in rats receiving alkylating agents. Rats were given a single intravenous administration of cyclophosphamide (CY) at a dose of 3, 10 or 30 mg/kg. Spleen weights and cellularity were decreased in the rats treated with 30 mg/kg. Suppressed PFC response wes observed in the rats receiving 10 mg/kg or more. In the rats treated with CY at 1, 3 or 10 mg/kg for 7 days, spleen weights and cellularity and PFC response were reduced at doses of 3 mg/kg or more. Treatment with the other alkylating agents, however, had a different consequence. Namely, in the rats treated with nitromin once or for 7 days, spleen weights and cellularity were decreased at a dose lower than that causing a reduction in the PFC response. In the rats treated with melphalan or chlorambucil, the weights and cellularity of the spleen tended to be decreased at a dose lower than that suppressing the PFC response. Histologically, in the case of CY, the marginal zone was narrow with cellular depletion in the rates receiving 3 mg/kg...Continue Reading

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Citations

Jul 1, 2007·Environmental Toxicology and Pharmacology·Fen Xia HouWei Chen
Oct 25, 2008·Memórias do Instituto Oswaldo Cruz·Carla de Agostino BiellaLuciana Simon Pereira-Crott
Oct 30, 2008·Journal of Immunotoxicology·Ai KoganeiMasaru Nishikibe

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