Dose-response shift in the ability of gilts to remain pregnant following exogenous estradiol-17 beta exposure

Journal of Animal Science
W F PopeN L First

Abstract

Sixty mated gilts were assigned to a 2 X 6 factorial arrangement (n = 5) of day of injection (d 9 and 10 vs 12 and 13; d 0 = first day of estrus) and dose of estradiol-17 beta (0, .125, .5, 2, 8 and 32 mg X gilt-1 X d-1). Gilts were subsequently slaughtered on d 30; pregnancy was verified and percent embryonic survival calculated. A 64-fold shift in the dose-response curve for percent embryonic survival illustrated that the adverse effects of exogenous estradiol-17 beta were less when administered on d 12 and 13 as compared with d 9 and 10 (day X dose, P less than .01). This experiment demonstrated that the uterine-embryonic environment of d 12 and 13 pregnant gilts was more tolerant of exogenous estrogen alterations than that of d 9 and 10 pregnant gilts.

Citations

Sep 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M D AshworthR D Geisert
Mar 27, 2020·International Journal of Molecular Sciences·Monika M KaczmarekEmilia Przygrodzka
Mar 16, 2018·Molecular Reproduction and Development·Veronika L FlöterSusanne E Ulbrich

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