PMID: 3764334Jul 1, 1986Paper

Dose response studies using desferrioxamine and orally active chelators in a mouse model

Scandinavian Journal of Haematology
G J Kontoghiorghes

Abstract

59Fe excretion studies in response to different doses (4-9 mg) of three N-substituted 3-hydroxypyrid-4-one chelators, (1,2-dimethyl-3-hydroxypyrid-4-one, 1-ethyl-2-methyl-3-hydroxypyrid-4-one, 1-propyl-2-methyl-3-hydroxypyrid-4-one), and desferrioxamine in iron overloaded 59Fe lactoferrin labelled mice (40 +/- 4 g) have shown that the former chelators, when administered intraperitoneally and intragastrically, caused comparable 59Fe excretions to intraperitoneal desferrioxamine of equivalent doses. No apparent ill effects were observed when doses of 300 mg/kg were administered for 24 d.

References

Apr 6, 1985·Lancet·G J Kontoghiorghes
Apr 6, 1985·Lancet·M RubinsteinJ Hainaut
Jan 1, 1986·The Biochemical Journal·G J Kontoghiorghes
Apr 1, 1986·British Journal of Haematology·G J Kontoghiorghes, A V Hoffbrand
Sep 27, 1980·Lancet·S T Callender, D J Weatherall
Jul 23, 1983·Lancet·S C DaviesE R Huehns
Aug 20, 1983·Lancet·G KontoghiorghesE R Huehns
Jan 1, 1980·Annals of the New York Academy of Sciences·A CeramiK K Bhargava
Jan 14, 1980·FEBS Letters·L Bläckberg, O Hernell

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Citations

Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·C Hershko, D J Weatherall
Jan 1, 1988·FEMS Microbiology Immunology·J H BrockG J Kontoghiorghes
Sep 1, 1992·British Journal of Haematology·K PattanapanyasatR C Hider
Jun 27, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·George J KontoghiorghesAnnita Kolnagou
Oct 1, 1989·European Journal of Haematology·J Porter
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Thierry SimonartRobert Snoeck
Jan 1, 1990·Annals of the New York Academy of Sciences·C HershkoR W Grady
Jun 11, 1988·British Medical Journal·G J Kontoghiorghes
Oct 3, 2020·Environmental Science and Pollution Research International·Ekaterina PavlovaJuliana Ivanova
Apr 1, 1989·Baillière's Clinical Haematology·J B PorterR C Hider

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