A multicenter study of chlorthalidone was performed to determine the relative antihypertensive efficacy and side effects of doses lower than those usually recommended for therapy. After a 4-wk placebo control period 100 patients with mild hypertension were randomly assigned doubleblind to 12.5-, 25-, 50-, or 75-mg regimens of chlorthalidone or to placebo for 12 wk. The groups of patients taking 25, 50, and 75 mg had declines in blood pressure which were not significantly different from each other. Serum potassium decreased in the 50- and 75-mg groups but not significantly in the 25-mg group. We conclude that chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg with less perturbation of potassium. Use of smaller initial diuretic doses may provide equal efficacy with fewer side effects for many patients.
Controversies in hypertension: mild hypertension, isolated systolic hypertension, and the choice of a step one drug
A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension
Haemodynamic and hormonal changes during acute and chronic diuretic treatment in essential hypertension
Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study
Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement
Comparison of the antihypertensive efficacy and adverse reactions to two doses of bendrofluazide and hydrochlorothiazide and the effect of potassium supplementation on the hypotensive action of bendrofluazide: substudies of the Medical Research Council's trials of treatment of mild hypertension: Medical Research Council Working Party
Thiazide-induced dysglycemia: call for research from a working group from the national heart, lung, and blood institute
Strategies to improve the cardiovascular risk profile of thiazide-type diuretics as used in the management of hypertension
Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease
Diuretics and other antihypertensive drugs and glycemic control in non-insulin-dependent diabetics with hypertension. A survey by the Fukuoka Diabetes Clinic Group
Renal excretory responses to single and repeated administration of diuretics in healthy subjects: clinical connotations
Efficacy of chlorthalidone and hydrochlorothiazide in combination with amiloride in multiple doses on blood pressure in patients with primary hypertension: a protocol for a factorial randomized controlled trial
Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone
Comparison of two doses of betaxolol and placebo in hypertension: a randomized, double-blind cross-over trial
A pharmacokinetic and pharmacodynamic assessment of a combined slow-release metoprolol-chlorthalidone preparation
Network meta-analysis of efficacy and safety of chlorthalidone and hydrochlorothiazide in hypertensive patients.
Medical plan-analysis by computer: critiquing the pharmacologic management of essential hypertension
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.