PMID: 3759580Sep 1, 1986Paper

Dose response to preoperative irradiation in rectal cancer: implications for local control and complications associated with sphincter sparing surgery and abdominoperineal resection

International Journal of Radiation Oncology, Biology, Physics
G A FortierW C Constable

Abstract

Sixty patients with locally advanced adenocarcinoma of the rectum have been treated with preoperative high dose pelvic irradiation at the University of Virginia and Rockingham Memorial Hospital. Fifty-six patients showed no evidence of distant metastases at surgery. A dose response was observed with a 67% incidence of local control with 4000 cGy vs. 91% incidence with 5000 cGy. For the 52 patients who received curative surgery, there has been no local failure alone; 6 of these patients have had local plus distant failure and 16 have had distant failure only. Forty-three percent had anterior resection (AR) and 57% had abdominoperineal resections (APR). The major complication rate was 5% and the minor 14%. No increase in complications or decrease in local control was found between APR and AR. Five-year actuarial survival was 64% for lesions limited to the bowel wall, 59% for node negative lesions with disease extending through the wall, and 23% for node positive patients.

References

Jun 1, 1976·Cancer·K R StevensW S Fletcher
Apr 1, 1985·Diseases of the Colon and Rectum·S H RobersonT S Bloom
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·L L GundersonJ E Tepper
Mar 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·M M KligermanR Vera
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Jul 1, 1982·The British Journal of Surgery·R J NichollsI K Fry
Nov 1, 1982·Diseases of the Colon and Rectum·M ZorzittoN F Boyd

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Citations

Dec 1, 1992·Diseases of the Colon and Rectum·P Lechner, H Cesnik
Jan 9, 2008·Current Treatment Options in Oncology·Bert H O'Neil, Joel E Tepper
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K M TveitK E Giercksky
Nov 1, 1994·Annals of Surgery·W T SauseM Mohiuddin
Dec 18, 2001·Journal of Clinical Gastroenterology·David Blumberg, Ramesh K Ramanathan
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·R SuwinskiH R Withers
Sep 1, 1992·World Journal of Surgery·L Påhlman, B Glimelius
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H TatsuzakiC G Willett
Jan 1, 1989·Cancer Investigation·B D Minsky, A M Cohen
Dec 11, 1999·Clinical Oncology : a Journal of the Royal College of Radiologists·R Glynne-JonesH Phillips
May 1, 1989·The British Journal of Surgery·D J GallowayM A Friedman
Sep 1, 1992·Cancer·C A Poulter
Sep 1, 1992·Cancer·B J Cummings

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